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Review
. 2022 Jul 22:12:956926.
doi: 10.3389/fonc.2022.956926. eCollection 2022.

New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance

Audrey Sirvent  1 , Kevin Espie  1 , Evangelia Papadopoulou  1 , Dana Naim  1 , Serge Roche  1
Affiliations
Review

New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance

Audrey Sirvent et al. Front Oncol. .

Abstract

The tumor microenvironment facilitates cancer progression and therapeutic resistance. Tumor collagens and their architecture play an essential role in this process. However, little is known about the mechanisms by which tumor cells sense and respond to this extracellular matrix environment. Recently, the Discoidin Domain Receptor 1 (DDR1), a collagen receptor and tyrosine kinase has emerged as an important player in this malignant process, although the underlying signaling mechanisms remain unclear. Here, we review new DDR1 functions in tumor dormancy following dissemination, immune exclusion and therapeutic resistance induced by stromal collagens deposition. We also discuss the signaling mechanisms behind these tumor activities and the therapeutic strategies aiming at targeting these collagens-dependent tumor responses.

Keywords: Keywords: collagen; immune evasion; metastasis; receptor; therapeutic resistance; tumor dormancy; tumor microenvironment; tyrosine kinase.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance. (A) A model on DDR1 signaling during DTC dormancy and metastatic reactivation induced by TME collagens. (B) A model on DDR1 signaling during therapeutic resistance and immune exclusion induced TME collagens.
See this image and copyright information in PMC

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