Clinical Effect of Microneedle Injection Combined with Blood Transfusion in the Treatment of Severe Anemia Complicated with Vitiligo under Regenerative Medical Technology

Abstract

To explore the clinical efficacy of microneedle injection combined with blood transfusion in the treatment of severe anemia complicated with vitiligo based on regenerative medical technology and provide the theoretical basis for the adoption of microneedle technology, 60 patients with severe anemia complicated with vitiligo were selected as research objects. With 15 patients in each group, they were randomly assigned to the control group (calcipotriol ointment external application), observation group A (external application of moist exposed burn ointment (MEBO), observation group B (external application of MEBO combined with blood transfusion), and observation group C (microneedle injection of MEBO combined with blood transfusion). Blood indexes and plaque recovery of patients in different periods were detected. The total protein (TP) content in group C (62.3 ± 3.3 g/L and 64.3 ± 2.88 g/L) was remarkably higher than that in the control group (51.3 ± 3.17 g/L and 52.4 ± 3.17 g/L) and group A (52.6 ± 2.91 g/L and 51.8 ± 2.98 g/L)) at the 5th and 7th weeks after the treatment (P < 0.05). The albumin (ALB) content in group C (42.9 ± 3.28 g/L and 45.3 ± 3.1 g/L) was signally higher than that in the control group (41.8 ± 3.44 g/L and 41.9 ± 3.23 g/L) and group A (41.3 ± 2.91 g/L and 42.1 ± 3.02 g/L) at the 5th and 7th weeks after the treatment, and the content was markedly higher than that in group B at 5th week (P < 0.05). The wound healing rates of group C at the 3rd, 5th, and 7th weeks after the treatment (38.44%, 56.6%, and 90.23%) were greatly higher than those of the control group, group A, and group B (P < 0.05). Besides, the wound healing rate of group B was higher than that of the control group and group A (40.3% and 75.8%) at the 5th and 7th weeks after the treatment (P < 0.05). To sum up, based on regenerative medical technology, microneedle injection (microneedling is a derma roller process that pricks the skin with minuscule needles. The goal of the treatment is to develop new collagen and skin tissue, resulting in skin that is smoother, firmer, and more toned) combined with blood transfusion had a good therapeutic effect on patients with severe anemia complicated with vitiligo, which could manifestly improve the blood indexes and skin plaques of patients, with a good clinical adoption effect.

Figure 1

Principle of the drug introduced by microneedles: (a) principle of the drug introduced by the microneedles; (b) skin melanocytes.

Figure 2

Blood indexes of patients before treatment: (a) the absolute values of white blood cells, neutrophils, and the total number of lymphocytes; (b) comparison of ALB among the four groups; (c) comparison of CLB among the four groups.

Figure 3

Microscopic images of the skin of patients with vitiligo: (a, b) images with magnification (×10); (c, d) images with magnification (×40); (e, f) images with magnification (×100).

Figure 4

Changes in patients' blood indexes after treatment: (a) changes in TP; (b) changes in ALB; (c) changes in GLB. Note: a meant that compared with the control group, P < 0.05; b meant that compared with group A, P < 0.05; c meant that compared with group B, P < 0.05.

Figure 5

Improvement of skin symptoms of patients: (a–d) the control group, group A, group B, and group C.

Figure 6

Evaluation of the therapeutic effect of patients in the four groups: (a–d) the control group, group A, group B, and group C; (e) comparison of the cure rate among the four groups. Note: a meant that compared with the control group, P < 0.05; b meant that compared with group A, P < 0.05; c meant that compared with group B, P < 0.05.

Figure 7

Comparison of wound healing rate of patients in the four groups. Note: a meant that compared with the control group, P < 0.05; b meant that compared with group A, P < 0.05; c meant that compared with group B, P < 0.05.