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Review
. 2022 Jul 23:2022:3645038.
doi: 10.1155/2022/3645038. eCollection 2022.

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Saeid Vazifeh  1 , Parya Kananpour  1 , Mahna Khalilpour  1 , Sajjad Vazifeh Eisalou  1 , Michael R Hamblin  2   3
Affiliations
Review

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Saeid Vazifeh et al. Biomed Res Int. .

Abstract

Background: Lepidium sativum (garden cress) is a member of the Brassicaceae family that has been utilized for medicinal and culinary purposes in centuries. Anti-inflammatory, antioxidant, immunomodulatory, hepatoprotective, antihypertensive, antiasthmatic, and hypoglycemic properties are found in various portions of the plant. The anti-inflammatory, antioxidant, and immunomodulatory effects of L. sativum were the subject of this review.

Methods: The required information was gathered by searching the Web of Science, PubMed, and Scopus databases for the terms anti-inflammatory, antioxidant, immunomodulatory, immune system, and Lepidium sativum. Up until February 2022, the search was conducted.

Results: TNF-, IL-6, IL-1, NO, iNOS, and HO-1 levels were reduced, indicating that L. sativum has anti-inflammatory and immunomodulatory properties. Flavonoids, alkaloids, cyanogenic glycosides, tannins, glucosinolates, sterols, and triterpenes are the key chemical components that contribute to the anti-inflammatory effects. In peritoneal neutrophils, L. sativum reduced oxidative stress by scavenging free radicals, as evidenced by a drop in superoxide anion and an increase in glutathione.

Conclusion: The anti-inflammatory, antioxidant, and immunomodulatory activities of L. sativum could be explored in clinical trials to treat inflammatory and immune system illnesses.

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Conflict of interest statement

MRH declares the following potential conflicts of interest: Scientific Advisory Boards: Transdermal Cap Inc., Cleveland, OH; Hologenix Inc. Santa Monica, CA; Vielight, Toronto, Canada; JOOVV Inc., Minneapolis-St. Paul, MN; Consulting; USHIO Corp., Japan; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany. The other authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Ethnobotanical information about Lepidium sativum.
Figure 2
Figure 2
Summary of anti-inflammatory and immunomodulatory Lepidium sativum effects.
See this image and copyright information in PMC

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