Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 23:2022:3645038.
doi: 10.1155/2022/3645038. eCollection 2022.

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Saeid Vazifeh  1 , Parya Kananpour  1 , Mahna Khalilpour  1 , Sajjad Vazifeh Eisalou  1 , Michael R Hamblin  2   3
Affiliations
Review

Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum

Saeid Vazifeh et al. Biomed Res Int. .

Abstract

Background: Lepidium sativum (garden cress) is a member of the Brassicaceae family that has been utilized for medicinal and culinary purposes in centuries. Anti-inflammatory, antioxidant, immunomodulatory, hepatoprotective, antihypertensive, antiasthmatic, and hypoglycemic properties are found in various portions of the plant. The anti-inflammatory, antioxidant, and immunomodulatory effects of L. sativum were the subject of this review.

Methods: The required information was gathered by searching the Web of Science, PubMed, and Scopus databases for the terms anti-inflammatory, antioxidant, immunomodulatory, immune system, and Lepidium sativum. Up until February 2022, the search was conducted.

Results: TNF-, IL-6, IL-1, NO, iNOS, and HO-1 levels were reduced, indicating that L. sativum has anti-inflammatory and immunomodulatory properties. Flavonoids, alkaloids, cyanogenic glycosides, tannins, glucosinolates, sterols, and triterpenes are the key chemical components that contribute to the anti-inflammatory effects. In peritoneal neutrophils, L. sativum reduced oxidative stress by scavenging free radicals, as evidenced by a drop in superoxide anion and an increase in glutathione.

Conclusion: The anti-inflammatory, antioxidant, and immunomodulatory activities of L. sativum could be explored in clinical trials to treat inflammatory and immune system illnesses.

PubMed Disclaimer

Conflict of interest statement

MRH declares the following potential conflicts of interest: Scientific Advisory Boards: Transdermal Cap Inc., Cleveland, OH; Hologenix Inc. Santa Monica, CA; Vielight, Toronto, Canada; JOOVV Inc., Minneapolis-St. Paul, MN; Consulting; USHIO Corp., Japan; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany. The other authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Ethnobotanical information about Lepidium sativum.
Figure 2
Figure 2
Summary of anti-inflammatory and immunomodulatory Lepidium sativum effects.
See this image and copyright information in PMC

References

    1. Cassidy F. G. In: Dictionary of American Regional English . Hall J. H., Von Schneidemesser L., editors. Cambridge, Massachusetts: Belknap Press of Harvard University Press; 1985.
    1. Staub J., Buchert E. Exceptional Herbs for your Garden . Layton, UT, USA: Gibbs Smith; 2008.
    1. Munro D. B. Vegetables of Canada . NRC Research Press; 1997.
    1. Boswell J. T., Sowerby J. English Botany; or, Coloured Figures of British Plants . George Bell & Sons; 1883.
    1. AL-SNAFI AE. Chemical constituents and pharmacological effects of Lepidium sativum-a review. International Journal of Current Pharmaceutical Research . 2019;11(6):1–10. doi: 10.22159/ijcpr.2019v11i6.36338. - DOI

MeSH terms