Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug 1:15:4169-4179.
doi: 10.2147/IDR.S374835. eCollection 2022.

Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021

Endalk Birrie  1 , Ermias Sisay  2 , Nigusie Selomon Tibebu  2 , Birhanu Desu Tefera  1 , Mulusew Zeleke  1 , Zenebe Tefera  1
Affiliations

Neonatal Sepsis and Associated Factors Among Newborns in Woldia and Dessie Comprehensive Specialized Hospitals, North-East Ethiopia, 2021

Endalk Birrie et al. Infect Drug Resist. .

Abstract

Introduction: Neonatal sepsis is a clinical illness characterized by infection-related signs and symptoms in the first month of life, with or without bacteremia. Septicemia, meningitis, pneumonia, arthritis, osteomyelitis, and urinary tract infections are all examples of systemic illnesses that can affect newborns. Hence, the main aim of this study was to assess the prevalence and factors associated with neonatal sepsis among newborns in Woldia and Dessie Comprehensive Specialized Hospitals, northeast Ethiopia, from January 1 to July 30, 2021.

Methods: This institution-based cross-sectional study was conducted from January 1 to July 30, 2021, on 344 randomly selected neonates who visited the hospital. A systematic random sampling technique was used to select samples, and data were collected using a pre-tested standardized questionnaire. For data entry and analysis, Epi Data version 4.1 and SPSS version 24 applications were used, respectively. The goodness-of-fit was tested by the Hosmer-Lemeshow statistic test. Bivariable and multivariable binary logistic regressions were used to identify associated factors at a 95% confidence interval. Significance was considered at p-value <0.05.

Results: In this study, the prevalence of neonatal sepsis was 79.4% (95% CI: 75.2-83.6%). Maternal UTI/STI history [AOR: 3.1; 95% CI (1.5-7.1)], gestational age <37 weeks [AOR: 4.4; 95% CI (1.0-8.9)], PROM [AOR: 4.9; 95% CI (2.5-6.8)], and new-born resuscitation history [AOR: 2.3; 95% CI (1.5-4.3)] were all significantly associated with neonatal sepsis.

Conclusion: This study indicates that the proportion of neonatal sepsis is high. A history of maternal PROM, being a preterm neonate, a history of maternal UTI/STIs, and having received resuscitation at birth were identified as risk factors for neonatal sepsis.

Keywords: Ethiopia; hospitals; neonatal infection; neonatal intensive care unit; neonatal sepsis; north east.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Schematic diagram of sampling procedure among neonates in Woldia and Dessie Comprehensive Specialized Hospitals, north-east Ethiopia, 2021 (n = 344).
Figure 2
Figure 2
Prevalence of neonatal sepsis among neonates in Woldia and Dessie Comprehensive Specialized Hospitals, from January 1 to July 30, 2021.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Polin RA, Papile LA, Baley JE, et al.;The COMMITTEE ON FETUS AND NEWBORN. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129(5):1006–1015. doi:10.1542/peds.2012-0541 - DOI - PubMed
    1. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014;27(1):21–47. doi:10.1128/CMR.00031-13 - DOI - PMC - PubMed
    1. Schuchat A. Neonatal group B streptococcal disease — screening and prevention. N Engl J Med. 2000;343(3):209–210. doi:10.1056/NEJM200007203430310 - DOI - PubMed
    1. Edwards MS, Gonik B. Preventing the broad spectrum of perinatal morbidity and mortality through group B streptococcal vaccination. Vaccine. 2013;31:D66–71. doi:10.1016/j.vaccine.2012.11.046 - DOI - PubMed
    1. Weiss SL, Peters MJ, Alhazzani W, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020;46(Suppl 1):10–67. doi:10.1007/s00134-019-05878-6 - DOI - PMC - PubMed

LinkOut - more resources