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Review
. 2022 Jul 22:16:964060.
doi: 10.3389/fnins.2022.964060. eCollection 2022.

Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review

Jiecheng Guo  1 , Wai Leung Ambrose Lo  2 , Huijing Hu  1 , Li Yan  1 , Le Li  1
Affiliations
Review

Transcranial ultrasound stimulation applied in ischemic stroke rehabilitation: A review

Jiecheng Guo et al. Front Neurosci. .

Abstract

Ischemic stroke is a serious medical condition that is caused by cerebral vascular occlusion and leads to neurological dysfunction. After stroke, patients suffer from long-term sensory, motor and cognitive impairment. Non-invasive neuromodulation technology has been widely studied in the field of stroke rehabilitation. Transcranial ultrasound stimulation (TUS), as a safe and non-invasive technique with deep penetration ability and a tiny focus, is an emerging technology. It can produce mechanical and thermal effects by delivering sound waves to brain tissue that can induce the production of neurotrophic factors (NFs) in the brain, and reduce cell apoptosis and the inflammatory response. TUS, which involves application of an acoustic wave, can also dissolve blood clots and be used to deliver therapeutic drugs to the ischemic region. TUS has great potential in the treatment of ischemic stroke. Future advancements in imaging and parameter optimization will improve the safety and efficacy of this technology in the treatment of ischemic stroke.

Keywords: drug delivery; intervention; stroke; thrombosis; transcranial ultrasound.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanism of transcranial ultrasound stimulation (TUS) in stroke rehabilitation.
See this image and copyright information in PMC

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