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Review
. 2022 Jul 29:15:4349-4358.
doi: 10.2147/JIR.S355568. eCollection 2022.

Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review

Ameena Mohammed  1 , Arunasree M Kalle  2 , Pallu Reddanna  2
Affiliations
Review

Managing SARS-CoV2 Infections Through Resolution of Inflammation by Eicosanoids: A Review

Ameena Mohammed et al. J Inflamm Res. .

Abstract

Severe Corona Virus Disease is characterized by angiocentric inflammation of lungs and cytokine storm leading to potentially fatal multiple organ failure. Several studies have shown the high levels of pro-inflammatory cytokines, indicative of a poor prognosis in COVID-19. Eicosanoids play an important role in the induction of inflammation and cytokine production, while anti-inflammatory and pro-resolving properties of some eicosanoic acid derivatives enable inflamed tissues to return to homeostasis through the resolution of inflammation by aiding the clearance of cell debris and downregulation of pro-inflammatory stimulants. This review attempts to provide an overall insight on the eicosanoids synthesis and their role in the resolution of inflammation in the context of Corona Virus infection.

Keywords: COVID-19; cyclooxygenases; cytochrome P450; eicosanoids; lipid mediators of inflammation; lipoxygenases; polyunsaturated fatty acids.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Overview of cyclooxygenase (COX) and lipoxygenase (LOX) pathways, generating prostanoids and leukotrienes, respectively, in response to inflammatory stimuli.
Figure 2
Figure 2
The role of eicosanoids in the mediation of inflammation and resolution through class-switching and thus in the maintenance of homeostasis.
Figure 3
Figure 3
An interplay of pro-and anti-lipid mediators in mediating the cytokine storm and the potential therapeutic role of specialized pro-resolving mediators (SPMs) in the resolution of inflammation during SARS CoV-2 infection.
See this image and copyright information in PMC

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