Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 29:2022:7439878.
doi: 10.1155/2022/7439878. eCollection 2022.

Oxidative Stress-Induced Protein of SESTRIN2 in Cardioprotection Effect

Huang Rongjin  1 , Chen Feng  1 , Ke Jun  1 , Lin Shirong  1
Affiliations
Review

Oxidative Stress-Induced Protein of SESTRIN2 in Cardioprotection Effect

Huang Rongjin et al. Dis Markers. .

Abstract

Because of the rich mitochondria and high energy metabolic requirements, excessive oxidative stress generated by ROS is a key pathogenic mechanism in heart disease. SESTRIN2, the well-known antioxidant protein, plays a vital role in diminishing the production and accumulation of ROS, thus sparing cells from oxidative damage. From this new perspective, we first examine SESTRIN2 structure-function relationships; then, we describe how SESTRIN2 expression is regulated under oxidative stress conditions, emphasizing SESTRIN2's antioxidant mechanism via multiple signal transductions; and finally, we discuss SESTRIN2's role in a variety of oxidative stress-related cardiac diseases, including age-related heart disease, diabetic cardiomyopathy, ischemia-reperfusion myocardial injury, septic cardiomyopathy, and chronic cardiac insufficiency. The goal of this review is to identify the SESTRIN2 protein as a potential biomarker and new therapy target for oxidative stress-related cardiac diseases.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no potential conflicts of interest.

Figures

Figure 1
Figure 1
Schematic representation of the full-length gene sequence of SESN2 showing the three structural domains SESN-A, SESN-B, and SESN-C; schematic representation of the spatial structure of SESTRIN2 showing the SESN-A redox site (C125), the SESN-C physical interaction site with GATOR2 and the leucine binding site.
Figure 2
Figure 2
Schematic diagram of the biological effects of SESTRIN2 against oxidative stress.
See this image and copyright information in PMC

References

    1. Roth G. A., Mensah G. A., Johnson C. O., et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. Journal of the American College of Cardiology . 2020;76(25):2982–3021. doi: 10.1016/j.jacc.2020.11.010. - DOI - PMC - PubMed
    1. Sack M. N., Fyhrquist F. Y., Saijonmaa O. J., Fuster V., Kovacic J. C. Basic biology of oxidative stress and the cardiovascular system: part 1 of a 3-part series. Journal of the American College of Cardiology . 2017;70(2):196–211. doi: 10.1016/j.jacc.2017.05.034. - DOI - PMC - PubMed
    1. Griendling K. K., Touyz R. M., Zweier J. L., et al. Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American Heart Association. Circulation Research . 2016;119(5):e39–e75. doi: 10.1161/RES.0000000000000110. - DOI - PMC - PubMed
    1. Sies H., Jones D. P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nature Reviews Molecular Cell Biology . 2020;21(7):363–383. doi: 10.1038/s41580-020-0230-3. - DOI - PubMed
    1. Lee J. H., Budanov A. V., Park E. J., et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science . 2010;327(5970):1223–1228. doi: 10.1126/science.1182228. - DOI - PMC - PubMed