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Review
. 2022 Jul 22:9:961507.
doi: 10.3389/fnut.2022.961507. eCollection 2022.

Polysaccharide immunization and colorectal cancer: A systematic review and network meta-analysis

Yuefeng Chen  1 , Xinnan Pan  2 , Baoming Tian  3   4   5 , Yajun Hu  1
Affiliations
Review

Polysaccharide immunization and colorectal cancer: A systematic review and network meta-analysis

Yuefeng Chen et al. Front Nutr. .

Abstract

Polysaccharides have a variety of biological activities, and in the anti-tumor field, they produce tumor suppressive effects by regulating the polarization of tumor-associated macrophages (TAMs). In immunotherapy, it has significant activities in modulating cytokines and antibody production. We reviewed them and selected CD24, an immune target, for meta-analysis with colorectal cancer (CRC) to investigate the correlation between CD24 expression and CRC. Correlation of CD24 positive expression with clinical-pathological features: age, sex, Duke's stage, diameter, depth of invasion, degree of differentiation, and lymph node metastasis. It showed that: CD24 expression in CRC was significantly correlated with advanced nuclear grade of CRC, lymph node metastasis, Duke's stage of CRC and age of CRC patients, while there was no significant correlation with gender, tumor diameter and invasion depth. The aim is to clarify the specific mechanism of polysaccharide immune anti-tumor, combined with targeted site-specific anti-solid tumor.

Keywords: CD24; colorectal cancer; immune; polysaccharides; prognosis.

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Conflict of interest statement

BT was employed by the company Zhejiang Institute of Modern TCM and Natural Medicine Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Document retrieval flow chart.
FIGURE 2
FIGURE 2
Forest map of correlation between CD24 expression and high-level nuclear classification.
FIGURE 3
FIGURE 3
Forest map of correlation between CD24 expression and lymph node metastasis.
FIGURE 4
FIGURE 4
Forest map related to CD24 expression and dukes staging.
FIGURE 5
FIGURE 5
Forest map related to CD24 expression and age.
FIGURE 6
FIGURE 6
Forest map related to CD24 expression and gender.
FIGURE 7
FIGURE 7
Forest map related to CD24 expression and tumor diameter.
FIGURE 8
FIGURE 8
Forest map related to CD24 expression and infiltration depth.
See this image and copyright information in PMC

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