Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Nov 1;206(9):1055-1057.
doi: 10.1164/rccm.202208-1459ED.

Mucins MUC5AC and MUC5B in the Airways: MUCing around Together

Mehmet Kesimer  1
Affiliations
Editorial

Mucins MUC5AC and MUC5B in the Airways: MUCing around Together

Mehmet Kesimer. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
An illustration of the mucociliary apparatus of human (large) airways with ciliated and secretory (goblet) cells covered with a sheet of mucus. As reported by Hoang and colleagues (13), MUC5AC (red) and MUC5B (green) are packaged/stored mostly together but also separately in secretory granules (SG). After (or, perhaps, before) secretion, they interact and interpenetrate with each other to make a netlike gel framework for the formation of an effective airway mucus barrier. Surely, they are both essential macromolecular components of an effective protective mucus gel layer of healthy human proximal and large airways where the foreign particles, microbes, and so forth are trapped and cleared before they advance to the more distal and small airways and cause complications.
See this image and copyright information in PMC

Comment on

  • Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
    Hoang ON, Ermund A, Jaramillo AM, Fakih D, French CB, Flores JR, Karmouty-Quintana H, Magnusson JM, Fois G, Fauler M, Frick M, Braubach P, Hales JB, Kurten RC, Panettieri R, Vergara L, Ehre C, Adachi R, Tuvim MJ, Hansson GC, Dickey BF. Hoang ON, et al. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1081-1095. doi: 10.1164/rccm.202202-0309OC. Am J Respir Crit Care Med. 2022. PMID: 35776514 Free PMC article.

References

    1. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med . 2004;350:2645–2653. - PubMed
    1. Thomson NC, Chaudhuri R, Messow CM, Spears M, MacNee W, Connell M, et al. Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Respir Med . 2013;107:1501–1508. - PubMed
    1. Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, et al. Airway mucin concentration as a marker of chronic bronchitis. N Engl J Med . 2017;377:911–922. - PMC - PubMed
    1. Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, et al. The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis. Am J Respir Crit Care Med . 2015;192:182–190. - PMC - PubMed
    1. Carpenter J, Wang Y, Gupta R, Li Y, Haridass P, Subramani DB, et al. Assembly and organization of the N-terminal region of mucin MUC5AC: indications for structural and functional distinction from MUC5B. Proc Natl Acad Sci USA . 2021;118:e2104490118. - PMC - PubMed