Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;38(10):1349-1361.
doi: 10.1007/s00383-022-05190-3. Epub 2022 Aug 8.

Scoping review of recent evidence on the management of pediatric urolithiasis: summary of meta-analyses, systematic reviews and relevant randomized controlled trials

Michael E Chua #  1   2   3 , Jin Kyu Kim #  4 , Jessica M Ming  5 , Keara N De Cotiis  6   4   7 , Stephen S Yang  8 , Mandy Rickard  6   4 , Armando J Lorenzo  6   4 , Joana Dos Santos  6   4
Affiliations

Scoping review of recent evidence on the management of pediatric urolithiasis: summary of meta-analyses, systematic reviews and relevant randomized controlled trials

Michael E Chua et al. Pediatr Surg Int. 2022 Oct.

Abstract

This scoping review aimed to evaluate and summarize the recent 10 year pediatric urolithiasis literature with a particular focus on systematic reviews, randomized-controlled trials (RCT) and meta-analysis. The systematic literature search performed on September 1, 2021, restricted to the recent 10 years, focused on pediatric urolithiasis that are RCTs, meta-analysis and systematic reviews. The summarized literature included etiology, diagnostics, medical and surgical management. GRADE criteria are used to evaluate and standardize the reporting of evidence quality. A total of 33 relevant articles were included. The recent high-level studies included topics of genetic and diet association with pediatric stone formation, diagnostic assessment, medical management intervention including medical dissolution and expulsion therapy. The study extended to include the efficacy and safety of extracorporeal lithotripsy, percutaneous nephrolithotomy and retrograde intrarenal surgery. However, evidence quality was ranked "very-low" or "low". Based on the GRADE criteria downgrading of the quality level was due to heterogeneity and low precision. A majority of the RCTs were categorized as having a "high" to "uncertain" risk of bias. The relevant RCTs, meta-analyses and systematic reviews within the past decade are of low quality. Consequently, the research provided no clear evidence-based recommendations for managing pediatric urolithiasis. More rigorous research and high-quality studies are needed to determine the best practices.

Keywords: Evidence-based medicine; Pediatric; Scoping review; Urolithiasis.

PubMed Disclaimer

References

    1. Barreto L, Jung JH, Abdelrahim A, Ahmed M, Dawkins GPC, Kazmierski M (2019) Reprint-medical and surgical interventions for the treatment of urinary stones in children: a cochrane review. Can Urol Assoc J 13(10):334–341. https://doi.org/10.5489/cuaj.5787 - DOI - PubMed - PMC
    1. Taguchi K, Cho SY, Ng AC et al (2019) The urological association of Asia clinical guideline for urinary stone disease. Int J Urol 26(7):688–709. https://doi.org/10.1111/iju.13957 - DOI - PubMed
    1. Radmayr C, Bogaert G, Dogan HS, Kočvara R, Nijman JM, Stein R, Tekgul S, Undre S (2019) EAU guidelines on paediatric urology. In: EAU guidelines, edition presented at the annual EAU Congress Barcelona. Undre EAU Guidelines on Paediatric Urology© European Association of Urology, 2019
    1. NICE Guideline-Renal and ureteric stones: assessment and management: NICE (2019) Renal and ureteric stones: assessment and management. BJU International 123(2):220–232. https://doi.org/10.1111/bju.14654 - DOI
    1. Chua ME, Ming JM, De Cotiis KN, Kim JK, Yang SS, Farhat WA, Dos Santos J (2021) Review summary of recent “high-level” evidence on the management of pediatric urinary stones. SN Compr Clin Med 202(3):2301–2311. https://doi.org/10.1007/s42399-021-01016-w - DOI

Publication types

LinkOut - more resources