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Comment
. 2022 Aug 16;119(33):e2211222119.
doi: 10.1073/pnas.2211222119. Epub 2022 Aug 8.

Interplay between Rho, H-NS, spurious transcription, and Salmonella gene regulation

James M Slauch  1
Affiliations
Comment

Interplay between Rho, H-NS, spurious transcription, and Salmonella gene regulation

James M Slauch. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
Regulation of the SPI-1 T3SS. In the “off” state, H-NS silences the hilD promoter region, and there is not enough HilD activity to overcome this repression. Rho, working through NusG, is blocking spurious transcripts initiated outside this region by RNA polymerase (RNAP). If these transcripts escape Rho action, H-NS is dislodged from the DNA by the transcription complex. This lowers the threshold of HilD activity required to autoactivate, leading to the “on” state.
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References

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