Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases

Nasreen Hassoun-Kheir¹, C Henri van Werkhoven², Jake Dunning³, Thomas Jaenisch⁴, Janko van Beek⁵, Julia Bielicki⁶, Christopher C Butler⁷, Bruno Francois⁸, Stephan Harbarth¹, Ana C Hernandez Padilla⁸, Peter Horby³, Marion Koopmans⁹, James Lee³, Jesús Rodriguez-Baño¹⁰, Evelina Tacconelli¹¹, Yrene Themistocleous³, Alike W van der Velden², Marc Bonten², Herman Goossens¹², Marlieke E A de Kraker¹³; ECRAID-Base consortium

Affiliations

¹ Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva Switzerland.
² Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands.
³ Pandemic Sciences Institute, University of Oxford, Oxford, UK.
⁴ Heidelberg Institute of Global Health (HIGH), Heidelberg University Hospital, Heidelberg, Germany.
⁵ Department of Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
⁶ Institute for Infection and Immunity, St George's, University of London, London, UK; Infection Prevention and Control, Universitäts-Kinderspital Beider Basel, Basel, Switzerland.
⁷ Nuffield Department of Primary Care Health Sciences, Oxford University.
⁸ Medical-Surgical Intensive Care Unit and Inserm CIC 1435 & UMR 1092, CHU Limoges, Limoges, France.
⁹ Department of Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Pandemic and Disaster Preparedness Research Centre, Rotterdam, the Netherlands.
¹⁰ Infectious Diseases and Microbiology, Hospital Universitario Virgen Macarena, Department of Medicine, University of Sevilla, Biomedicine Institute of Sevilla (IBiS), CSIC, Sevilla, Spain; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
¹¹ Department of Infectious Diseases, University of Verona, Verona, Italy.
¹² Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
¹³ Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva Switzerland. Electronic address: marlieke.dekraker@hcuge.ch.

PMID: 35940566
PMCID: PMC9354481
DOI: 10.1016/j.cmi.2022.07.024

Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases

Nasreen Hassoun-Kheir et al. Clin Microbiol Infect. 2022 Dec.

. 2022 Dec;28(12):1528-1532.

doi: 10.1016/j.cmi.2022.07.024. Epub 2022 Aug 5.

Authors

Affiliations

¹ Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva Switzerland.
² Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, the Netherlands.
³ Pandemic Sciences Institute, University of Oxford, Oxford, UK.
⁴ Heidelberg Institute of Global Health (HIGH), Heidelberg University Hospital, Heidelberg, Germany.
⁵ Department of Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
⁶ Institute for Infection and Immunity, St George's, University of London, London, UK; Infection Prevention and Control, Universitäts-Kinderspital Beider Basel, Basel, Switzerland.
⁷ Nuffield Department of Primary Care Health Sciences, Oxford University.
⁸ Medical-Surgical Intensive Care Unit and Inserm CIC 1435 & UMR 1092, CHU Limoges, Limoges, France.
⁹ Department of Viroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Pandemic and Disaster Preparedness Research Centre, Rotterdam, the Netherlands.
¹⁰ Infectious Diseases and Microbiology, Hospital Universitario Virgen Macarena, Department of Medicine, University of Sevilla, Biomedicine Institute of Sevilla (IBiS), CSIC, Sevilla, Spain; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
¹¹ Department of Infectious Diseases, University of Verona, Verona, Italy.
¹² Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
¹³ Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva Switzerland. Electronic address: marlieke.dekraker@hcuge.ch.

PMID: 35940566
PMCID: PMC9354481
DOI: 10.1016/j.cmi.2022.07.024

No abstract available

Keywords: Antimicrobial resistance; Emerging infectious diseases; Perpetual observational studies; Research network; Study methodology.

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References

1. Sabin N.S., Calliope A.S., Simpson S.V., Arima H., Ito H., Nishimura T., et al. Implications of human activities for (re)emerging infectious diseases, including covid-19. J Physiol Anthropol. 2020;39:29. - PMC - PubMed
1. Goossens H., Derde L., Horby P., Bonten M. The european clinical research response to optimise treatment of patients with covid-19: lessons learned, future perspective, and recommendations. Lancet Infect Dis. 2022;22:e153–e158. - PMC - PubMed
1. Angus D.C., Berry S., Lewis R.J., Al-Beidh F., Arabi Y., van Bentum-Pujik W., et al. The remap-cap (randomized embedded multifactorial adaptive platform for community-acquired pneumonia) study. Rationale and design. Ann Am Thorac Soc. 2020;17:879–891. - PMC - PubMed
1. Butler C.C., van der Velden A.W., Bongard E., Saville B.R., Holmes J., Coenen S., et al. Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial. Lancet. 2020;395:42–52. - PubMed
1. Årdal C., Balasegaram M., Laxminarayan R., McAdams D., Outterson K., Rex J.H., et al. Antibiotic development–economic, regulatory and societal challenges. Nat Rev Microbiol. 2020;18:267–274. - PubMed

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Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases

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Perpetual observational studies: new strategies to support efficient implementation of observational studies and randomized trials in infectious diseases

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