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. 1987 May;91(1):149-54.
doi: 10.1111/j.1476-5381.1987.tb08993.x.

Acetylcholinesterase activity rises in rat cerebrospinal fluid post-ictally; effect of a substantia nigra lesion on this rise and on seizure threshold

M E Appleyard, A R Green, S A Greenfield

Acetylcholinesterase activity rises in rat cerebrospinal fluid post-ictally; effect of a substantia nigra lesion on this rise and on seizure threshold

M E Appleyard et al. Br J Pharmacol. 1987 May.

Abstract

The activity of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF) of rats increased by 53% following an electroconvulsive shock (ECS) while non-specific cholinesterase (nsChE) activity was unchanged. A flurothyl-induced seizure failed to elicit a change in the AChE activity of CSF. A bilateral lesion of the substantia nigra pars reticulata abolished the rise in AChE activity in the CSF but did not diminish the increase of seizure threshold which follows a convulsion. These data suggest that AChE is released from the substantia nigra following a seizure but indicate that the change is not associated with the rise in seizure threshold which occurs.

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