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Review
. 2022 Nov;45(11):1622-1633.
doi: 10.1007/s00270-022-03228-6. Epub 2022 Aug 8.

SIRT in 2025

Francesca Romana Ponziani #  1 , Francesco Santopaolo #  1 , Alessandro Posa  2 , Maurizio Pompili  1   3 , Alessandro Tanzilli  2 , Marta Maestri  1 , Maria Pallozzi  1 , Francesca Ibba  1 , Riccardo Manfredi  2   3 , Antonio Gasbarrini #  1   3 , Roberto Iezzi #  4   5
Affiliations
Review

SIRT in 2025

Francesca Romana Ponziani et al. Cardiovasc Intervent Radiol. 2022 Nov.

Abstract

Selective internal radiation therapy represents an endovascular treatment option for patients with primary liver malignancies, in different clinical stages. Potential applications of this treatment are in early-stage hepatocellular carcinoma, as a curative option, or in combination with systemic treatments in intermediate and advanced-stages. This review, based on existing literature and ongoing trials, will focus on the future of this treatment in patients with hepatocellular carcinoma, in combination with systemic treatments, or with the use of new devices and technological developments; it will also describe new potential future indications and structural and organizational perspectives.

Keywords: Chemotherapy; HCC; Immunotherapy; Locoregional treatment; SIRT; TARE; TKI; Yttrium-90.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

References

    1. Mazzaferro V, Sposito C, Bhoori S, Romito R, Chiesa C, Morosi C, Maccauro M, Marchianò A, Bongini M, Lanocita R, Civelli E, Bombardieri E, Camerini T, Spreafico C. Yttrium-90 radioembolization for intermediate-advanced hepatocellular carcinoma: a phase 2 study. Hepatology. 2013;57(5):1826–1837. doi: 10.1002/hep.26014. - DOI - PubMed
    1. Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol. 2021;S0168–8278(21):02223–2226. doi: 10.1016/j.jhep.2021.11.018. - DOI - PMC - PubMed
    1. Biederman DM, Titano JJ, Bishay VL, Durrani RJ, Dayan E, Tabori N, Patel RS, Nowakowski FS, Fischman AM, Kim E. Radiation segmentectomy versus TACE combined with microwave ablation for unresectable solitary hepatocellular carcinoma Up to 3 cm: a propensity score matching study. Radiology. 2017;283(3):895–905. doi: 10.1148/radiol.2016160718. - DOI - PubMed
    1. Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, Aranda Aguilar E, Bardelli A, Benson A, Bodoky G, Ciardiello F, D'Hoore A, Diaz-Rubio E, Douillard JY, Ducreux M, Falcone A, Grothey A, Gruenberger T, Haustermans K, Heinemann V, Hoff P, Köhne CH, Labianca R, Laurent-Puig P, Ma B, Maughan T, Muro K, Normanno N, Österlund P, Oyen WJ, Papamichael D, Pentheroudakis G, Pfeiffer P, Price TJ, Punt C, Ricke J, Roth A, Salazar R, Scheithauer W, Schmoll HJ, Tabernero J, Taïeb J, Tejpar S, Wasan H, Yoshino T, Zaanan A, Arnold D. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 2016;27(8):1386–1422. doi: 10.1093/annonc/mdw235. - DOI - PubMed
    1. Vitale A, Burra P, Frigo AC, Trevisani F, Farinati F, Spolverato G, Volk M, Giannini EG, Ciccarese F, Piscaglia F, Rapaccini GL. Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study. J hepatol. 2015;62(3):617–624. doi: 10.1016/j.jhep.2014.10.037. - DOI - PubMed

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