Ocular emergencies visits after corneal transplantation at a tertiary eye care hospital in Saudi Arabia

Abstract

Purpose: To evaluate the characteristics of patients with post-keratoplasty complications and their presentation at an emergency center.

Design: Retrospective one-armed cohort study.

Methods: Data were evaluated on patients who underwent corneal grafts in 2019 and presented to an emergency unit. Data were collected on patient demographics, presenting symptoms, clinical details, diagnosis at emergency visit, final diagnosis, best-corrected visual acuity (BCVA) at presentation and at the last follow-up after management. Severe visual impairment (SVI) and graft rejection were tested for correlations to other factors.

Results: The study sample was comprised of 149 eyes of 124 patients with a mean age of 27.5 years. Keratoconus was the indication for keratoplasty in 94 (75.8%) patients. The main presenting symptoms were pain 57 (38.3%) and red eye in 52 (34.9%) patients. The median interval between emergency visit and keratoplasty was 1.6 years. There were 63 (42.3%) patients who had emergency visits due to suture-related problems. The rates of SVI and graft rejection at the time of discharge after managing emergencies in eyes with previous keratoplasty were 14.1% (95% CI 8.5; 19.7) and 13.4 (95% CI 7.9; 18.9), respectively. Keratoconus (OR = 22.8) and young age (P < 0.001) were negatively associated with SVI after management.

Conclusion: Patients with keratoplasty are at high risk for severe vision loss and should be counseled to seek urgent eye care for early detection and management of sight-threatening complications to improve graft survival and vision.

Keywords: Graft rejection; Keratitis; Keratoplasty; Ocular emergency.