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. 2022 Aug 9;80(1):185.
doi: 10.1186/s13690-022-00947-7.

Obesity phenotypes related to musculoskeletal disorders; a cross-sectional study from RaNCD cohort

Sheno Karimi  1 , Yahya Pasdar  2 , Behrooz Hamzeh  2 , Azad Ayenehpour  1 , Fatemeh Heydarpour  3 , Farjam Goudarzi  4
Affiliations

Obesity phenotypes related to musculoskeletal disorders; a cross-sectional study from RaNCD cohort

Sheno Karimi et al. Arch Public Health. .

Abstract

Background: This study was evaluated the association between obesity phenotypes and risk of lower torso musculoskeletal disorders including low back pain (LBP), low back stiffness (LBS), arthralgia, and joint stiffness in Ravansar non-communicable diseases (RaNCD) cohort study.

Methods: In this cross-sectional study, 6940 adults were examined for the presence of lower torso musculoskeletal disorders by a physician. Obesity phenotypes including metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) were defined based on the International Diabetes Federation, as well as, body mass index > 30 kg/m2. Metabolically unhealthy non-obesity (MUNO) phenotype was considered as unhealthy metabolic without obesity.

Results: The prevalence of LBP, LBS, arthralgia, and joint stiffness in MHO, MUO, and MUNO were significantly higher than in healthy participants compared to obesity phenotypes. Logistic regression showed that MHO phenotype was significantly increased with risk of LBP (OR: 1.19, CI 95%: 1.01-1.41), LBS (OR: 1.44, CI 95%: 1.12-1.86), arthralgia (OR: 1.54, CI 95%: 1.33-1.78), and joint stiffness (OR: 1.84, CI 95%: 1.35-2.52). Moreover, MUO phenotype was positively associated with risk of LBS (OR: 1.46, CI 95%: 1.09-1.94) and arthralgia (OR: 1.66, CI 95%: 1.41-1.96). In addition, MUNO phenotype was associated with a higher risk of arthralgia (OR: 1.21, CI 95%: 1.06-1.37).

Conclusion: All three phenotypes, MHO, MUO and MUNO were significantly increased the risk of arthralgia. However, MHO phenotype was significantly associated with a higher risk of all examined lower torso musculoskeletal disorders in the current study.

Keywords: Arthralgia, Persian; Low back pain; Low back stiffness; Metabolically unhealthy; Obesity.

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Conflict of interest statement

All authors declare that they have no conflict of interests.

Figures

Fig. 1
Fig. 1
Flow chart of the sample selection
Fig. 2
Fig. 2
Binary regression odds ratios and 95% confidence intervals for A Low back pain; B Low back stiffness; C Arthralgia, and D Joint stiffness across categories of obesity phenotypes. MHNO: metabolically healthy non-obese; MHO: metabolically healthy obese; MUNO: metabolically unhealthy non-obese; MUO: metabolically unhealthy obese
See this image and copyright information in PMC

References

    1. Luan HD, Hai NT, Xanh PT, Giang HT, Van Thuc P, Hong NM, et al. Musculoskeletal disorders: prevalence and associated factors among district hospital nurses in Haiphong, Vietnam. BioMed Res Int. 2018;2018. - PMC - PubMed
    1. Nguyen TH, Hoang DL, Hoang TG, Pham MK, Bodin J, Dewitte JD, et al. Prevalence and characteristics of multisite musculoskeletal symptoms among district hospital nurses in Haiphong, Vietnam. BioMed Res Int. 2020;2020. - PMC - PubMed
    1. van der Gaag WH, Roelofs PD, Enthoven WT, van Tulder MW, Koes BW. Non‐steroidal anti‐inflammatory drugs for acute low back pain. Cochrane Database Syst Rev. 2020;4(4):Cd013581. - PMC - PubMed
    1. Tagliaferri SD, Miller CT, Owen PJ, Mitchell UH, Brisby H, Fitzgibbon B, et al. Domains of chronic low back pain and assessing treatment effectiveness: a clinical perspective. Pain Pract. 2020;20(2):211–225. doi: 10.1111/papr.12846. - DOI - PubMed
    1. LaxmaiahManchikanti M, Radomir KM. Low back pain and diagnostic lumbar facet joint nerve blocks: Assessment of prevalence, false-positive rates, and a philosophical paradigm shift from an acute to a chronic pain model. Pain Physician. 2020;23:519–529. - PubMed

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