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Review
. 2022 Aug 8;15(1):69.
doi: 10.1186/s13041-022-00946-3.

Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection

Vaishnavi Sundar  1 , Jay P McLaughlin  2 , Thangavel Samikkannu  3
Affiliations
Review

Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection

Vaishnavi Sundar et al. Mol Brain. .

Abstract

HIV is a major global public threat burdening society, yet the exact mechanism of HIV pathogenesis needs to be elucidated. In the era of epigenetic therapy, N-terminal acetylation (Nt-acetylation) changes induced by viral infection might play a critical role in virus-host interactions in HIV infection. The mitochondrial epigenetic mechanism, predominantly Nt acetylation, holds HIV immunopathogenesis and is vastly unexplored. The challenge is to single out the specific pathological role of NAT changes in HIV-associated neurodegeneration. Therefore, this nano review aims to shine light on Nt acetylation in HIV pathogenesis, which we believe can lead to effective future therapeutic strategies against HIV-associated neurodegeneration.

Keywords: Epigenetics; HIV; Neurodegeneration; Nt acetyltransferase; Nt-acetylation.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Proposed mechanisms of HIV disease progression influenced by the epigenetic signatures of N-terminal acetylation-impaired immunity and neuropathogenesis in microglial cells. HIV human immunodeficiency virus, NAT N-terminal acetylation, NAA N-alpha acetyltransferases, HYPK huntingtin interacting protein K
See this image and copyright information in PMC

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