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. 2022 Sep;29(9):103396.
doi: 10.1016/j.sjbs.2022.103396. Epub 2022 Jul 25.

The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats

R S Rajasree  1 , Sibi P Ittiyavirah  2 , Punnoth Poonkuzhi Naseef  3 , Mohamed Saheer Kuruniyan  4 , Muhammed Elayadeth-Meethal  5 , S Sankar  6
Affiliations

The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats

R S Rajasree et al. Saudi J Biol Sci. 2022 Sep.

Abstract

In different parts of the world, Cucumis melo Linn. (C melo) is used for its medicinal properties. The present study examined the effects of a methanolic extract of C melo Linn. (F1 hybrid, MECM) on benign prostatic hyperplasia in adult male Wistar rats and evaluated its anti-inflammatory activity in vivo. MECM treatment reduced prostate weight mildly. Histopathological studies showed that the extract produced a strong protective effect against the development of BPH by testosterone. The MECM also showed protection from testosterone-induced benign prostatic hyperplasia (BPH). MECM was tested against carrageenan-induced inflammation in rats' paws to determine its anti-inflammatory activity. It was shown that MECM had a pronounced effect on the inflammatory response in the late phase, i.e., one hour after carrageenan injection. Prostaglandins and nitric oxide are primarily responsible for this phase indicating that MECM can modify the production and release of prostaglandin and nitric oxide. A novel formulation containing C melo may be able to treat the conditions mentioned above.

Keywords: Bioactive compounds; Drug discovery; Inflammation; Inflammation-associate diseases: Benign prostatic hyperplasia (BPH); Medicinal plants; Phytochemicals.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Histopathological studies showing protective effect of methanolic extract of Cucumis melo Linn. (MECM) against the development of benign prostatic hyperplasia (BPH) by testosterone in Wistar rats.
Fig. 2
Fig. 2
Effect of Methanolic extract of Cucumis melo Linn. (MECM) on prostatic hypertrophy in Wistar rats.
Fig. 3
Fig. 3
Percentage reduction in paw edema at 3rd, 4th, and 6th h after administration of methanolic extract of Cucumis melo Linn. (MECM) in Wistar rats.
Fig. 4
Fig. 4
Increase in paw volume in mice over time in response to treatment with methanolic extract of Cucumis melo Linn. (MECM) in Wistar rats.
See this image and copyright information in PMC

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