A Narrative Review of Ocular Surface Disease Related to Anti-Glaucomatous Medications

doi:10.1007/s40123-022-00557-0

Review

. 2022 Oct;11(5):1681-1704.

doi: 10.1007/s40123-022-00557-0. Epub 2022 Aug 9.

A Narrative Review of Ocular Surface Disease Related to Anti-Glaucomatous Medications

Xiaoyu Zhou^{1

2}, Xinyue Zhang^{1

2}, Dengming Zhou², Yang Zhao^{1

2}, Xuanchu Duan^{3

4}

Affiliations

¹ Changsha Aier Eye Hospital, Changsha, Hunan Province, China.
² The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
³ Changsha Aier Eye Hospital, Changsha, Hunan Province, China. duanxchu@csu.edu.cn.
⁴ Aier School of Ophthalmology, Central South University, Changsha, Hunan Province, China. duanxchu@csu.edu.cn.

PMID: 35943668
PMCID: PMC9437175
DOI: 10.1007/s40123-022-00557-0

Review

A Narrative Review of Ocular Surface Disease Related to Anti-Glaucomatous Medications

Xiaoyu Zhou et al. Ophthalmol Ther. 2022 Oct.

. 2022 Oct;11(5):1681-1704.

doi: 10.1007/s40123-022-00557-0. Epub 2022 Aug 9.

Authors

Xiaoyu Zhou^{1

2}, Xinyue Zhang^{1

2}, Dengming Zhou², Yang Zhao^{1

2}, Xuanchu Duan^{3

4}

Affiliations

¹ Changsha Aier Eye Hospital, Changsha, Hunan Province, China.
² The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
³ Changsha Aier Eye Hospital, Changsha, Hunan Province, China. duanxchu@csu.edu.cn.
⁴ Aier School of Ophthalmology, Central South University, Changsha, Hunan Province, China. duanxchu@csu.edu.cn.

PMID: 35943668
PMCID: PMC9437175
DOI: 10.1007/s40123-022-00557-0

Abstract

Topical anti-glaucomatous medications are still the most important measure to lower intraocular pressure. Large number of studies have confirmed that long-term use of anti-glaucomatous eye drops, especially containing benzalkonium chloride, a preservative, can cause or aggravate ocular surface injury. Ocular surface diseases damage the ocular microenvironmental health status, reduce the patients' compliance with the treatment, and finally affect the treatment result. Therefore, the ocular surface management of patients with glaucoma is very important. This includes the selection of drugs that are better tolerated according to individual conditions, preservative-free formulations, drugs that protect against ocular surface disease, or selecting surgery and laser treatment, to prevent the damage to the ocular surface by topical anti-glaucomatous drugs.

Keywords: Anti-glaucomatous medications; Benzalkonium chloride; Ocular surface disease; Preservative-free formulation.

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References

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1. Zhang X, Vadoothker S, Munir WM, et al. Ocular surface disease and glaucoma medications: a clinical approach. Eye Contact Lens. 2019;45(1):11–18. doi: 10.1097/ICL.0000000000000544. - DOI - PMC - PubMed
1. Baudouin C, Kolko M, Melik-Parsadaniantz S, et al. Inflammation in glaucoma: from the back to the front of the eye, and beyond. Prog Retin Eye Res. 2021;83:100916. doi: 10.1016/j.preteyeres.2020.100916. - DOI - PubMed
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[1] Kang JM, Tanna AP. Glaucoma. Med Clin North Am. 2021;105(3):493–510. doi: 10.1016/j.mcna.2021.01.004. - DOI - PubMed

[2] Kang JM, Tanna AP. Glaucoma. Med Clin North Am. 2021;105(3):493–510. doi: 10.1016/j.mcna.2021.01.004. - DOI - PubMed

[3] Zhang X, Vadoothker S, Munir WM, et al. Ocular surface disease and glaucoma medications: a clinical approach. Eye Contact Lens. 2019;45(1):11–18. doi: 10.1097/ICL.0000000000000544. - DOI - PMC - PubMed

[4] Zhang X, Vadoothker S, Munir WM, et al. Ocular surface disease and glaucoma medications: a clinical approach. Eye Contact Lens. 2019;45(1):11–18. doi: 10.1097/ICL.0000000000000544. - DOI - PMC - PubMed

[5] Baudouin C, Kolko M, Melik-Parsadaniantz S, et al. Inflammation in glaucoma: from the back to the front of the eye, and beyond. Prog Retin Eye Res. 2021;83:100916. doi: 10.1016/j.preteyeres.2020.100916. - DOI - PubMed

[6] Baudouin C, Kolko M, Melik-Parsadaniantz S, et al. Inflammation in glaucoma: from the back to the front of the eye, and beyond. Prog Retin Eye Res. 2021;83:100916. doi: 10.1016/j.preteyeres.2020.100916. - DOI - PubMed

[7] Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II epidemiology report. Ocul Surf. 2017;15(3):334–365. doi: 10.1016/j.jtos.2017.05.003. - DOI - PubMed

[8] Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II epidemiology report. Ocul Surf. 2017;15(3):334–365. doi: 10.1016/j.jtos.2017.05.003. - DOI - PubMed

[9] Azuara-Blanco A, Bagnasco L, Bagnis A, et al. European Glaucoma Society Terminology and Guidelines for Glaucoma. 5th edn. Br J Ophthalmol. 2021;105(Suppl 1):1–169. doi: 10.1136/bjophthalmol-2021-egsguidelines. - DOI - PubMed

[10] Azuara-Blanco A, Bagnasco L, Bagnis A, et al. European Glaucoma Society Terminology and Guidelines for Glaucoma. 5th edn. Br J Ophthalmol. 2021;105(Suppl 1):1–169. doi: 10.1136/bjophthalmol-2021-egsguidelines. - DOI - PubMed

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A Narrative Review of Ocular Surface Disease Related to Anti-Glaucomatous Medications

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A Narrative Review of Ocular Surface Disease Related to Anti-Glaucomatous Medications

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