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1 Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, 1081 HV, Amsterdam, The Netherlands. a.griffioen@amsterdamumc.nl.
2 School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Patrycja.Nowak-Sliwinska@unige.ch.
1 Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, 1081 HV, Amsterdam, The Netherlands. a.griffioen@amsterdamumc.nl.
2 School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Patrycja.Nowak-Sliwinska@unige.ch.
Research on cell death mechanisms gets a lot of attention. This is understandable as it underlies biology in general, as well as the insight in pathological conditions and the development of opportunities for therapeutic intervention. Over the last years a steady rise in the number of scientific reports and in the impact of this literature on the different mechanisms of programmed cell death can be observed. A number of new concepts are highlighted.
Melanoma cell undergoing paraptosis after exposure to the vitamin E derivative δ-Tocotrienol (δ-TT).…
Fig. 1
Melanoma cell undergoing paraptosis after exposure to the vitamin E derivative δ-Tocotrienol (δ-TT). This TEM image shows that A375 human melanoma cells treated with δ-TT exhibit vacuolation, dilated endoplasmic reticulum (ER) cisternae and swollen mitochondria (m), as specific features of cells undergoing paraptosis. This image is taken from Raimondi M et al. Apoptosis 26(5–6):277–92, 2021 [4]
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