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. 2022 Aug 9;17(8):e0272839.
doi: 10.1371/journal.pone.0272839. eCollection 2022.

Global burden of SARS-CoV-2 infection, hospitalization and case fatality rate among COVID-19 vaccinated individuals and its associated factors: A systematic review and meta-analysis protocol

Alex Durand Nka  1   2   3 , Aude Christelle Ka'e  1   2 , Yagai Bouba  1   2   4 , Ezechiel Ngoufack Jagni Semengue  1   2   3 , Michel Carlos Tommo Tchouaket  1 , Désiré Takou  1 , Willy Pabo  5 , Nadine Fainguem  1   2   3 , Samuel Martin Sosso  1 , Vittorio Colizzi  1   2   3 , Carlo-Federico Perno  6 , Joseph Fokam  1   7
Affiliations

Global burden of SARS-CoV-2 infection, hospitalization and case fatality rate among COVID-19 vaccinated individuals and its associated factors: A systematic review and meta-analysis protocol

Alex Durand Nka et al. PLoS One. .

Abstract

Background: COVID-19 has been the most important public health concern worldwide since 2020. Several vaccines are now available to help in controlling COVID-19 associated morbidity and mortality. This study will aim to provide the global and regional prevalence of SARS-CoV-2 infection as well as an estimate of disease severity among COVID-19 vaccinated individuals.

Materials and methods: In order to determine the global burden of SARS-CoV-2 infection among vaccinated individuals, we will systematically extract and review papers from PubMed/MEDLINE, Excerpta Medica database (EMBASE), Cochrane Central Register of Controlled Trials (CENTRAL), Science direct and Cumulative Index to Nursing and Allied Health Literature (CINAHL). All the studies describing the prevalence and/or disease severity (hospitalization and case fatality rate) data of COVID-19 among individuals who received a partial or complete dose of WHO-approved COVID-19 vaccines will be eligible. A random effect model will be used to calculate the pooled prevalence and to estimate the disease severity. Subgroup analysis will be performed to explore the association between the number of vaccine doses received and the COVID-19 burdens.

Discussion: This systematic review and meta-analysis will provide the global estimate data on pooled prevalence, hospitalization and case fatality rates of COVID-19 among vaccinated individuals. Moreover, the factors associated with reinfection and disease severity will be equally investigated in the meta-analysis. The results of this study will contribute in the understanding and estimation of the global burden of COVID-19 among vaccinated individuals. Findings will provide meaningful information for the success of the current global rollout of COVID-19 vaccination strategies and pave the way for future interventions.

Systematic review registration: CRD42021273074.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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