COVID-19 and Inborn Errors of Immunity

doi:10.1152/physiol.00016.2022

Review

. 2022 Nov 1;37(6):0.

doi: 10.1152/physiol.00016.2022. Epub 2022 Aug 9.

COVID-19 and Inborn Errors of Immunity

Ottavia M Delmonte¹, Riccardo Castagnoli^{1

2

3}, Luigi D Notarangelo¹

Affiliations

¹ Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
² Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
³ Pediatric Clinic, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

PMID: 35944006
PMCID: PMC9550578
DOI: 10.1152/physiol.00016.2022

Review

COVID-19 and Inborn Errors of Immunity

Ottavia M Delmonte et al. Physiology (Bethesda). 2022.

. 2022 Nov 1;37(6):0.

doi: 10.1152/physiol.00016.2022. Epub 2022 Aug 9.

Authors

Ottavia M Delmonte¹, Riccardo Castagnoli^{1

2

3}, Luigi D Notarangelo¹

Affiliations

¹ Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
² Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
³ Pediatric Clinic, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

PMID: 35944006
PMCID: PMC9550578
DOI: 10.1152/physiol.00016.2022

Abstract

Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation. Considering the predisposition to develop severe and chronic infections, it is crucial to understand the clinical evolution of COVID-19 in IEI patients. This review analyzes clinical outcomes following SARS-CoV-2 infection, as well as response to COVID-19 vaccines in patients with IEI.

Keywords: COVID-19; COVID-19 vaccine; SARS-COV-2; inborn errors of immunity; primary immune deficiency.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

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References

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[1] Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, Martin-Moro F, Razanamahery J, Riches JC, Zwicker J, Patell R, Vekemans MC, Scarfo L, Chatzikonstantinou T, Yildiz H, Lattenist R, Mantzaris I, Wood WA, Hicks LK. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood 136: 2881–2892, 2020. doi:10.1182/blood.2020008824. - DOI - PMC - PubMed

[2] Vijenthira A, Gong IY, Fox TA, Booth S, Cook G, Fattizzo B, Martin-Moro F, Razanamahery J, Riches JC, Zwicker J, Patell R, Vekemans MC, Scarfo L, Chatzikonstantinou T, Yildiz H, Lattenist R, Mantzaris I, Wood WA, Hicks LK. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood 136: 2881–2892, 2020. doi:10.1182/blood.2020008824. - DOI - PMC - PubMed

[3] Azzi Y, Bartash R, Scalea J, Loarte-Campos P, Akalin E. COVID-19 and solid organ transplantation: a review article. Transplantation 105: 37–55, 2021. doi:10.1097/TP.0000000000003523. - DOI - PubMed

[4] Azzi Y, Bartash R, Scalea J, Loarte-Campos P, Akalin E. COVID-19 and solid organ transplantation: a review article. Transplantation 105: 37–55, 2021. doi:10.1097/TP.0000000000003523. - DOI - PubMed

[5] Marcus N, Frizinsky S, Hagin D, Ovadia A, Hanna S, Farkash M, Maoz-Segal R, Agmon-Levin N, Broides A, Nahum A, Rosenberg E, Kuperman AA, Dinur-Schejter Y, Berkun Y, Toker O, Goldberg S, Confino-Cohen R, Scheuerman O, Badarneh B, Epstein-Rigbi N, Etzioni A, Dalal I, Somech R. Minor clinical impact of COVID-19 pandemic on patients with primary immunodeficiency in Israel. Front Immunol 11: 614086, 2020. doi:10.3389/fimmu.2020.614086. - DOI - PMC - PubMed

[6] Marcus N, Frizinsky S, Hagin D, Ovadia A, Hanna S, Farkash M, Maoz-Segal R, Agmon-Levin N, Broides A, Nahum A, Rosenberg E, Kuperman AA, Dinur-Schejter Y, Berkun Y, Toker O, Goldberg S, Confino-Cohen R, Scheuerman O, Badarneh B, Epstein-Rigbi N, Etzioni A, Dalal I, Somech R. Minor clinical impact of COVID-19 pandemic on patients with primary immunodeficiency in Israel. Front Immunol 11: 614086, 2020. doi:10.3389/fimmu.2020.614086. - DOI - PMC - PubMed

[7] Meyts I, Bucciol G, Quinti I, Neven B, Fischer A, Seoane E, , et al. . Coronavirus disease 2019 in patients with inborn errors of immunity: an international study. J Allergy Clin Immunol 147: 520–531, 2021. doi:10.1016/j.jaci.2020.09.010. - DOI - PMC - PubMed

[8] Meyts I, Bucciol G, Quinti I, Neven B, Fischer A, Seoane E, , et al. . Coronavirus disease 2019 in patients with inborn errors of immunity: an international study. J Allergy Clin Immunol 147: 520–531, 2021. doi:10.1016/j.jaci.2020.09.010. - DOI - PMC - PubMed

[9] Milito C, Lougaris V, Giardino G, Punziano A, Vultaggio A, Carrabba M, , et al. . Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity. J Allergy Clin Immunol Pract 9: 2904–2906.e2, 2021. doi:10.1016/j.jaip.2021.04.017. - DOI - PMC - PubMed

[10] Milito C, Lougaris V, Giardino G, Punziano A, Vultaggio A, Carrabba M, , et al. . Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity. J Allergy Clin Immunol Pract 9: 2904–2906.e2, 2021. doi:10.1016/j.jaip.2021.04.017. - DOI - PMC - PubMed

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COVID-19 and Inborn Errors of Immunity

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COVID-19 and Inborn Errors of Immunity

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