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Randomized Controlled Trial
. 2022 Sep 1;41(9):728-730.
doi: 10.1097/INF.0000000000003585. Epub 2022 May 23.

Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial

Boubacar Coulibaly  1 , Dramane Kiemde  1 , Guillaume Zonou  1 , Ali Sié  1 , Clarisse Dah  1 , Mamadou Bountogo  1 , Jessica Brogdon  2 , Huiyu Hu  2 , Elodie Lebas  2 , Travis C Porco  2 , Thuy Doan  2 , Thomas M Lietman  2 , Catherine E Oldenburg  2   3   4
Affiliations
Randomized Controlled Trial

Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial

Boubacar Coulibaly et al. Pediatr Infect Dis J. .

Abstract

We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.

Trial registration: ClinicalTrials.gov NCT03676751.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

FIGURE 1.
FIGURE 1.
Prevalence of pneumococcal carriage (A), erythromycin (B), clindamycin (C), oxacillin (D), tetracycline (E), and trimethoprim-sulfamethoxazole (F) resistance by arm and study time point. Points indicate proportion of samples from which pneumococcus was isolated (for pneumococcal growth) or proportion of positive isolates that were resistant to the antibiotic. Bars indicate binomial 95% confidence intervals. Results from the placebo group are in gray and results from the azithromycin group are yellow.
See this image and copyright information in PMC

References

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