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. 2022 Aug 8;40(8):802-804.
doi: 10.1016/j.ccell.2022.07.007.

Untangling the tumorigenic role of homotrimeric collagen I

Claus Jørgensen  1
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Untangling the tumorigenic role of homotrimeric collagen I

Claus Jørgensen. Cancer Cell. .
Free article

Abstract

Pancreatic ductal adenocarcinoma is characterized by a complex microenvironment. In this issue of Cancer Cell, Chen and colleagues define an oncogenic role of tumor-cell-produced collagen I homotrimers, wherein tumor development is promoted by integrin α3/β1-dependent activation of tumor cell signaling and modulation of tumor microbiome and immunity.

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Declaration of interests The authors declare no competing interests.

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