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. 1987;24(3):197-201.
doi: 10.1007/BF00205629.

Canine lymphoma-associated antigens defined by murine monoclonal antibodies

Z Steplewski, K A Jeglum, C Rosales, N Weintraub

Canine lymphoma-associated antigens defined by murine monoclonal antibodies

Z Steplewski et al. Cancer Immunol Immunother. 1987.

Abstract

Lymphoma in dogs resembles human non-Hodgkin's lymphoma in pathological presentation, immunophenotype, and response to therapy, thus representing a good model for comparative studies with human disease. Monoclonal antibodies (MAbs) were derived from mice immunized with a dog lymphoma cell line. Three MAbs were selected for further application in immunophenotyping and immunotherapy. The binding specificities, antigen characterization, and isotypes for these MAbs are described.

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