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. 1987;24(3):225-30.
doi: 10.1007/BF00205634.

In vivo delayed rejection of tumors and inhibition of delayed-type hypersensitivity by HT-29 human colonic adenocarcinoma cell line

G J Pommier, F L Garrouste, D Bettetini, J M Culouscou, M M Remacle-Bonnet

In vivo delayed rejection of tumors and inhibition of delayed-type hypersensitivity by HT-29 human colonic adenocarcinoma cell line

G J Pommier et al. Cancer Immunol Immunother. 1987.

Abstract

Products secreted by HT-29 human colonic adenocarcinoma cells (DMEM-HT-29) mediated strong suppressive activity of in vitro lymphoproliferative responses to several mitogens. In vivo administration of DMEM-HT-29 both inhibited the afferent limb of delayed-type hypersensitivity against the Mc FiFi2(s) syngeneic fibrosarcoma and delayed the rejection of these tumor cells by immunized animals. Transfer experiments prior or after cell fractionation did not demonstrate suppressor cells induced by DMEM-HT-29. This suggests that DMEM-HT-29 produces its effect by directly interacting with macrophage and/or T cells at the sensitization stage of the antitumor immune response.

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References

    1. Allen JC, Smith CJ, Hussain JJ, Thomas JM, Gaugas JM. Inhibition of lymphocyte proliferation by polyamines requires ruminant-plasma polyamine oxidase. Eur J Biochem. 1979;102:153. - PubMed
    1. Autrup H. Methods in cell biology, vol 21. London: Academic Press; 1980. Explant culture of human colon; p. 385. - PubMed
    1. Bettetini D, Garrouste F, Remacle-Bonnet M, Culouscou JM, Marvaldi J, Pommier G. Enhancement of production of superoxide anion by human polymorphonuclear leukocytes exposed to products of HT-29 human colonic adenocarcinoma cell line. J Natl Cancer Inst. 1986;77:1225. - PubMed
    1. Bettetini D, Garrouste F, Remacle-Bonnet M, Culouscou J-M, Marvaldi J, Pommier G. Enhancement of production of superoxide anion by human monocytes exposed to products of HT-29 human colonic adenocarcinoma cell line. Int J Cancer. 1987;39:203. - PubMed
    1. Forni G, Varesio L, Giovarelli M, Cavallo G. Tumor associated antigens and their specific immune response. London: Academic Press; 1980. Dynamic state of spontaneous immune reactivity towards a mammary adenocarcinom; p. 167.

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