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Comment
. 2022 Sep;43(9):693-695.
doi: 10.1016/j.it.2022.07.009. Epub 2022 Aug 6.

Clonal hematopoiesis, inflammation, and cardiovascular disorders: a mitochondrial connection

Francesco Pileri  1 , Gioacchino Natoli  2
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Clonal hematopoiesis, inflammation, and cardiovascular disorders: a mitochondrial connection

Francesco Pileri et al. Trends Immunol. 2022 Sep.

Abstract

Mutations in two antagonistic regulators of DNA methylation, DNMT3A and TET2, are associated with clonal hematopoiesis and increased risk of cardiovascular disorders. Recently, Cobo et al. traced the mechanistic bases for such links to loss of mitochondrial integrity, cytoplasmic dispersion of mitochondrial DNA, and the subsequent activation of interferon-stimulated genes (ISGs) in macrophages.

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Declaration of interests None declared by authors.

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