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Review
. 2022 Oct;42(10):1392-1399.
doi: 10.1038/s41372-022-01483-6. Epub 2022 Aug 9.

Epidemiology of post-hemorrhagic ventricular dilatation in very preterm infants

Jehier Afifi  1 , Prakesh S Shah  2   3 , Xiang Y Ye  2 , Vibhuti Shah  3 , Bruno Piedboeuf  4 , Keith Barrington  5 , Edmond Kelly  3 , Walid El-Naggar  6 ; Canadian Neonatal Network Investigators
Collaborators, Affiliations
Review

Epidemiology of post-hemorrhagic ventricular dilatation in very preterm infants

Jehier Afifi et al. J Perinatol. 2022 Oct.

Abstract

Objective: To describe the incidence, trends, management's variability and short-term outcomes of preterm infants with severe post-hemorrhagic ventricular dilatation (sPHVD).

Methods: We reviewed infants <33 weeks' gestation who had PHVD and were admitted to the Canadian Neonatal Network between 2010 and 2018. We compared perinatal characteristics and short-term outcomes between those with sPHVD and those with mild/moderate PHVD and those with and without ventriculo-peritoneal (VP) shunt.

Results: Of 29,417 infants, 2439 (8%) had PHVD; rate increased from 7.3% in 2010 to 9.6% in 2018 (P = 0.005). Among infants with PHVD, sPHVD (19%) and VP shunt (29%) rates varied significantly across Canadian centers and between geographic regions (P < 0.01 and P = 0.0002). On multivariable analysis, sPHVD was associated with greater mortality, seizures and meningitis compared to mild/moderate PHVD.

Conclusions: Significant variability in sPHVD and VP shunt rates exists between centers and regions in Canada. sPHVD was associated with increased mortality and morbidities.

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References

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