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. 2022 Aug 9;22(1):142.
doi: 10.1186/s12880-022-00870-x.

Early diagnosis of spinal tuberculosis by magnetic resonance: perfusion weighted imaging in a rabbit model

Xiaochen Liu  1 , Yunlin Wang  1 , Wenxiao Jia  2
Affiliations

Early diagnosis of spinal tuberculosis by magnetic resonance: perfusion weighted imaging in a rabbit model

Xiaochen Liu et al. BMC Med Imaging. .

Abstract

Background: This study aimed to analyze the application value of magnetic resonance (MR)-perfusion weighted imaging (PWI) in the early imaging diagnosis of rabbit spinal tuberculosis.

Methods: Spinal tuberculosis model was established using ATCC25177 Mycobacterium tuberculosis strain in the lumbar spine of rabbits. Forty rabbits were divided into 2 groups: rabbits in the experiment group were injected with 0.2 ml of 5.0 mg/ml tuberculosis suspension (n = 30) and those in the control group were injected with 0.2 ml of normal saline (n = 10) after vertebrae drilling surgery. Routine MRI and MR-PWI were performed at 4, 6, and 8 weeks after surgery. The statistical difference in terms of perfusion parameter values in the early MR-PWI scan of spinal tuberculosis between two groups was analyzed. The receiver operating characteristic (ROC) curve analysis was conducted for the accuracy of MR-PWI parameters in the early diagnosis of spinal tuberculosis.

Results: Except time to peak, the other perfusion parameters in the experiment group were all increased with time. In addition, the difference between the two groups, as well as the differences at each time point was statistically significant (all P < 0.05). First-pass enhancement rate (Efirst), early enhancement rate (Ee), peak height (PH), maximum slope of increase (MSI), maximum signal enhancement rate (Emax) and signal enhancement rate (SER) showed high values in early diagnosing spinal tuberculosis.

Conclusion: The parameters including Efirst, Ee, PH, MSI, Emax and SER may provide valuable imaging evidence for the early diagnosis of spinal tuberculosis in clinical application.

Keywords: Hemodynamics; Perfusion parameters; Perfusion weighted imaging; Spinal tuberculosis.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
The characteristics of the dynamic changes of blood flow perfusion of microvessels inside the vertebra of spinal tuberculosis disease at 4 (A), 6 (B) and 8 (C) after weeks of infection in the experiment group. The left is the scan image of the region of interest (ROI), and the right is the pseudo-color image
Fig. 2
Fig. 2
The time-signal intensity curve (TIC) of magnetic resonance (MR)- Perfusion weighted imaging (PWI) at 4 (A), 6 (B) and 8 (C) weeks after infection in the experiment group
Fig. 3
Fig. 3
The receiver operating characteristic (ROC) curve analysis of early enhancement parameters. Efirst, First-pass enhancement rate; Vfirst, First-pass enhancement velocity; Ee, Early enhancement rate; Ve, Early enhancement velocity
Fig. 4
Fig. 4
The receiver operating characteristic (ROC) curve analysis of peak parameters and washout. PH peak height, TTP time to peak, MSI maximum slope of increase; Emax Maximum signal enhancement rate, SER Signal enhancement ratio
See this image and copyright information in PMC

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References

    1. Singh S, Dawar H, Das K, Mohapatra B, Prasad S. Functional and radiological outcomes of anterior decompression and posterior stabilization via posterior transpedicular approach in thoracic and thoracolumbar Pott's Disease: a retrospective study. Asian Spine J. 2017;11(4):618. doi: 10.4184/asj.2017.11.4.618. - DOI - PMC - PubMed
    1. Rajasekaran S, Soundararajan DCR, Shetty AP, Kanna RM. Spinal tuberculosis: current concepts. Glob Spine J. 2018;8(4_Suppl):96S–108S. doi: 10.1177/2192568218769053. - DOI - PMC - PubMed
    1. Qiao P, Zhao P, Gao Y, Bai Y, Niu G. Differential study of DCE-MRI parameters in spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis. Chin J Cancer Res. 2018;30(4):425–431. doi: 10.21147/j.issn.1000-9604.2018.04.05. - DOI - PMC - PubMed
    1. Lang N, Su M-Y, Yu HJ, Yuan H. Differentiation of tuberculosis and metastatic cancer in the spine using dynamic contrast-enhanced MRI. Eur Spine J. 2015;24(8):1729–1737. doi: 10.1007/s00586-015-3851-z. - DOI - PMC - PubMed
    1. Schirner M, Menrad A, Stephens A, Frenzel T, Hauff P, Licha K. Molecular imaging of tumor angiogenesis. Ann N Y Acad Sci. 2004;1014(1):67–75. doi: 10.1196/annals.1294.007. - DOI - PubMed

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