Multicenter Study

. 2022 Aug 9;22(1):201.

doi: 10.1186/s12902-022-01101-8.

Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study

Jiajia Chen^#¹, Yan Zhong^#², Haiyan Wei^#³, Shaoke Chen⁴, Zhe Su⁵, Lijun Liu⁶, Liyang Liang⁷, Ping Lu⁸, Linqi Chen⁹, Ruimin Chen¹⁰, Shining Ni¹¹, Xinli Wang¹², Li Li¹³, Yunfeng Wang¹⁴, Xu Xu¹⁵, Yanfeng Xiao¹⁶, Hui Yao¹⁷, Geli Liu¹⁸, Runming Jin¹⁹, Bingyan Cao¹, Di Wu¹, Chang Su¹, Wenjing Li¹, Miao Qin¹, Xiaoqiao Li¹, Xiaoping Luo²⁰, Chunxiu Gong²¹

Affiliations

¹ Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, No.56 Nanlishi Road, Xicheng District, 100045, Beijing, China.
² Department of Child Health Care, Hunan Children's Hospital, Changsha, 410007, China.
³ Department of Endocrinology and Metabolism, Genetics, Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University), Changsha, 450018, China.
⁴ Department of Genetics and Metabolism, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530005, China.
⁵ Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, 518038, China.
⁶ Department of Endocrinology, Genetics, and Metabolism, Hebei Children's Hospital, Shijiazhuang, 050031, China.
⁷ Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
⁸ Department of Pediatrics, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
⁹ Depatment of Endocrinology, Children's Hospital of Soochow University, Suzhou, 215025, China.
¹⁰ Department of Endocrinology, Geneticsand Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, 350005, China.
¹¹ Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
¹² Department of Pediatrics, Peking University Third Hospital, Beijing, 100191, China.
¹³ Department of Pediatrics, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
¹⁴ Department of Pediatrics, China-Japan Friendship Hospital, Beijing, 100029, China.
¹⁵ Department of Endocrinology, Wuxi Children's Hospital, Wuxi, 214023, China.
¹⁶ Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710004, China.
¹⁷ Department of Endocrinology and Metabolism, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.
¹⁸ Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, 300052, China.
¹⁹ Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
²⁰ Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. xpluo@tjh.tjmu.edu.cn.
²¹ Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, No.56 Nanlishi Road, Xicheng District, 100045, Beijing, China. chunxiugong@sina.com.

^# Contributed equally.

PMID: 35945517
PMCID: PMC9364582
DOI: 10.1186/s12902-022-01101-8

Multicenter Study

Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study

Jiajia Chen et al. BMC Endocr Disord. 2022.

. 2022 Aug 9;22(1):201.

doi: 10.1186/s12902-022-01101-8.

Authors

Affiliations

¹ Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, No.56 Nanlishi Road, Xicheng District, 100045, Beijing, China.
² Department of Child Health Care, Hunan Children's Hospital, Changsha, 410007, China.
³ Department of Endocrinology and Metabolism, Genetics, Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University), Changsha, 450018, China.
⁴ Department of Genetics and Metabolism, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530005, China.
⁵ Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, 518038, China.
⁶ Department of Endocrinology, Genetics, and Metabolism, Hebei Children's Hospital, Shijiazhuang, 050031, China.
⁷ Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
⁸ Department of Pediatrics, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
⁹ Depatment of Endocrinology, Children's Hospital of Soochow University, Suzhou, 215025, China.
¹⁰ Department of Endocrinology, Geneticsand Metabolism, Fuzhou Children's Hospital of Fujian Medical University, Fuzhou, 350005, China.
¹¹ Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
¹² Department of Pediatrics, Peking University Third Hospital, Beijing, 100191, China.
¹³ Department of Pediatrics, The First People's Hospital of Yunnan Province, Kunming, 650032, China.
¹⁴ Department of Pediatrics, China-Japan Friendship Hospital, Beijing, 100029, China.
¹⁵ Department of Endocrinology, Wuxi Children's Hospital, Wuxi, 214023, China.
¹⁶ Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710004, China.
¹⁷ Department of Endocrinology and Metabolism, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.
¹⁸ Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, 300052, China.
¹⁹ Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
²⁰ Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. xpluo@tjh.tjmu.edu.cn.
²¹ Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, No.56 Nanlishi Road, Xicheng District, 100045, Beijing, China. chunxiugong@sina.com.

^# Contributed equally.

PMID: 35945517
PMCID: PMC9364582
DOI: 10.1186/s12902-022-01101-8

Abstract

Background: To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature.

Methods: This real-world study enrolled children with short stature in 19 hospitals throughout China. They were treated with PEG-rhGH for 6 months. The starting dosage ranged from 0.10 to 0.20 mg/kg/week. The primary outcome was the change in height standard deviation score (ΔHt SDS).

Results: Five hundred and ten patients were included and grouped based on dosage as A (0.10-0.14 mg/kg/week), B (0.15-0.16 mg/kg/week), C (0.17-0.19 mg/kg/week), and D (0.20 mg/kg/week). The mean 6-month ΔHt SDS for the total cohort was 0.49 ± 0.27, and the means differed among the four dose groups (P = 0.002). The ΔHt SDS was lower in group A than in groups B (LSM difference [95%CI], -0.09 [-0.17, -0.01]), C (LSM difference [95%CI], -0.10 [-0.18, -0.02]), and D (LSM difference [95%CI], -0.13 [-0.21, -0.05]) after adjusting baseline covariates. There were no significant differences among groups B, C, and D. When the baseline IGF-1 was < -2 SDS or > 0 SDS, the △Ht SDS was not different among the four groups (P = 0.931 and P = 0.400). In children with baseline IGF-1 SDS of -2 ~ 0 SDS, a higher dosage was associated with a better treatment effect (P = 0.003), and the △Ht SDS was lower in older children than in younger ones (P < 0.001).

Conclusions: PEG-rhGH could effectively increase height in prepubertal short children. When the baseline IGF-1 was < -2 SDS, 0.10 mg/kg/week could be a starting dose. In other IGF-1 statuses, 0.15-0.20 mg/kg/week might be preferred.

Trial registration: ClinicalTrials.gov: NCT03249480 , retrospectively registered.

Keywords: Children; Multicenter; Polyethylene glycol recombinant human growth hormone; Real-world study; Short stature.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
The distribution of 6-month ΔHt SDS in different groups

**Fig. 2**
The 6-month ΔHt SDS distribution in different baseline IGF-1 SDS combined with different treatment dosages

See this image and copyright information in PMC

References

1. Barstow C, Rerucha C. Evaluation of Short and Tall Stature in Children. Am Fam Physician. 2015;92(1):43–50. - PubMed
1. Rogol AD, Hayden GF. Etiologies and early diagnosis of short stature and growth failure in children and adolescents. J Pediatr. 2014;164(5 Suppl):S1–14 e16. doi: 10.1016/j.jpeds.2014.02.027. - DOI - PubMed
1. Alatzoglou KS, Webb EA, Le Tissier P, Dattani MT. Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances. Endocr Rev. 2014;35(3):376–432. doi: 10.1210/er.2013-1067. - DOI - PubMed
1. Stanley T. Diagnosis of growth hormone deficiency in childhood. Curr Opin Endocrinol Diabetes Obes. 2012;19(1):47–52. doi: 10.1097/MED.0b013e32834ec952. - DOI - PMC - PubMed
1. Wit JM: ICPED. International Classification of Pediatric Endocrine Diagnoses. Short stature. http://www.icped.org/revisions/0/2015/diagnoses/#!/1. Accessed May 25, 2021; 2007.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

Associated data

Actions
- Search in PubMed
- Search in ClinicalTrials.gov

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study

Affiliations

Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Associated data

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous