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Review
. 2022 Aug 9;22(1):247.
doi: 10.1186/s12935-022-02670-3.

Exercise and colorectal cancer: prevention and molecular mechanisms

Ramin Amirsasan  1 , Maryam Akbarzadeh  2 , Shabnam Akbarzadeh  3
Affiliations
Review

Exercise and colorectal cancer: prevention and molecular mechanisms

Ramin Amirsasan et al. Cancer Cell Int. .

Abstract

Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and meta-analysis have demonstrated that exercise is significantly effective in lowering the risk of colorectal cancer. In addition, it is suggested as an effective therapeutic modality against this cancer type. Therefore, in this review, we will review comprehensibly the effects of exercise in preventing, treating, and alleviating the adverse effects of conventional therapeutic options in colorectal cancer. Moreover, the possible mechanisms underlying the positive effects of exercise and physical activity in colorectal cancer, including regulation of inflammation, apoptosis, growth factor axis, immunity, epigenetic, etc. will be also discussed.

Keywords: Colorectal cancer; Exercise; Mechanisms; Physical activity; Prevention.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
molecular mechanisms underlying therapeutic effects of exercise in cancer
Fig. 2
Fig. 2
molecular mechanisms of preventive effects of exercise in colorectal cancer
See this image and copyright information in PMC

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