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. 2022 Aug 9;23(1):638.
doi: 10.1186/s13063-022-06445-z.

Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach study protocol for a multi-center, stepped-wedge randomized controlled trial

Leslie W Young  1 , Songthip Ounpraseuth  2 , Stephanie L Merhar  3 , Alan E Simon  4 , Abhik Das  5 , Rachel G Greenberg  6 , Rosemary D Higgins  7 , Jeannette Lee  8 , Brenda B Poindexter  9 , P Brian Smith  6 , Michele Walsh  10 , Jessica Snowden  11 , Lori A Devlin  12 ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network and the NIH Environmental influences on Child Health Outcomes (ECHO) Program Institutional Development Awards States Pediatric Clinical Trials Network
Affiliations

Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach study protocol for a multi-center, stepped-wedge randomized controlled trial

Leslie W Young et al. Trials. .
No abstract available

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Conflict of interest statement

The authors declare that they have no completing interests.

Figures

Fig. 1
Fig. 1
Screening and enrollment procedures. *The site research team may obtain consent for the long-term follow-up portion of the study at any point during the hospital stay for infants who meet the trial’s inclusion criteria. To optimize recruitment it will permissible to obtain initial consent up to one month after discharge
Fig. 2
Fig. 2
Randomization Flow Diagram
See this image and copyright information in PMC

References

    1. Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012. J Perinatol. 2015;35(8):667. - PubMed
    1. Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009. JAMA. 2012;307(18):1934–1940. - PubMed
    1. Tolia VN, Patrick SW, Bennett MM, Murthy K, Sousa J, Smith PB, et al. Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs. New Engl J Med. 2015;372(22):2118–2126. - PubMed
    1. Hudak ML, Tan RC, Committee On D, Committee On F, Newborn, American Academy of P Neonatal drug withdrawal. Pediatrics. 2012;129(2):e540–e560. - PubMed
    1. Reddy UM, Davis JM, Ren Z, Greene MF. Opioid Use in Pregnancy NAS, Childhood Outcomes Workshop Invited S. Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes: Executive Summary of a Joint Workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation. Obstet Gynecol. 2017;130(1):10–28. - PMC - PubMed

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