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Review
. 2022 Aug 9;11(1):45.
doi: 10.1186/s40164-022-00298-7.

Role of m6A writers, erasers and readers in cancer

Zhen Fang  1 , Wentong Mei  1 , Chang Qu  1 , Jiongdi Lu  1 , Liang Shang  2 , Feng Cao  3 , Fei Li  4
Affiliations
Review

Role of m6A writers, erasers and readers in cancer

Zhen Fang et al. Exp Hematol Oncol. .

Abstract

The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions.

Keywords: Cancer; Erasers; N6-methyladenosine (m6A); Readers; Writers.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Effects of m6A modification in different types of RNA molecules (mRNA, tRNA, rRNA, circRNA, miRNA, lncRNA)
Fig. 2
Fig. 2
m6A regulators, as well as molecules and signaling pathways that can be regulated by m6A regulators. Red indicates regulators that play an oncogenic role, and blue indicates regulators that plat an anti-oncogenic role. a, b Writers. c, d Erasers. e, f Readers
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