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Randomized Controlled Trial
. 2022 Nov;54(11):2813-2818.
doi: 10.1007/s11255-022-03338-7. Epub 2022 Aug 10.

Efficacy of combination therapy with biofeedback and dapoxetine in lifelong premature ejaculation treatment: a prospective randomized study

Ali Haydar Yılmaz  1 , Ahmet Emre Cinislioglu  2 , Saban Oğuz Demirdöğen  2 , Fatih Kursat Yılmazel  2 , Emre Sam  2 , Ibrahim Karabulut  2 , Mahmut Koç  3 , Isa Özbey  4
Affiliations
Randomized Controlled Trial

Efficacy of combination therapy with biofeedback and dapoxetine in lifelong premature ejaculation treatment: a prospective randomized study

Ali Haydar Yılmaz et al. Int Urol Nephrol. 2022 Nov.

Abstract

Purpose: Premature ejaculation (PE) is a common sexual dysfunction that significantly affects the quality of life of the patient and their partner. We aimed to compare the efficacy and safety of the combination therapy with biofeedback-guided pelvic floor exercise therapy (BFT) and dapoxetine 30 mg.

Methods: Sixty-five patients diagnosed with lifelong PE were included in the study. Patients were divided into three groups as BFT, dapoxetine 30 mg and a combination of BFT and dapoxetine 30 mg. The patients were compared with the intravaginal ejaculatory latency time (IELT) pre-treatment and post-treatment 1st and 3rd months.

Results: The mean IELTs of the patients in Group 1 were 40 s in pre-treatment, 115 s at the end of the 4th week and 140 s at the end of the 12th week. The IELT values of the patients in Group 2 were 40 s in pre-treatment, 145 s in the 4th week and 170 s in the 12th week. The IELT values were calculated in Group 3 as 42.5 s in pre-treatment, 185 s in the 4th week and 205 s in the 12th week When the IELT was statistically compared between the groups at 1st and 3rd months, the duration in the combination group was found to increase significantly (p < 0.001).

Conclusion: Combination therapy with BFT and dapoxetine 30 mg in lifelong PE treatment is a good alternative with a low side effect profile and acceptable continuous efficiency.

Keywords: Biofeedback; Dapoxetine; Ejaculation; Pelvik floor; Premature.

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References

    1. Saitz TR, Serefoglu EC (2016) The epidemiology of premature ejaculation. Transl Androl Urol 5:409–415 - DOI
    1. Jannini EA, Lenzi A (2005) Epidemiology of premature ejaculation. Curr Opin Urol 15:399–403 - DOI
    1. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH et al (2005) A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2:492–497 - DOI
    1. Serefoglu EC, Mcmahon CG, Waldinger MD, Althof SE, Shindel A et al (2014) An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation. Sex Med 2:41–59 - DOI
    1. Rosenbaum TY (2007) Pelvic floor involvement in male and female sexual dysfunction and the role of pelvic floor rehabilitation in treatment: a literature review. J Sex Med 4:4–13 - DOI

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