Economic Evaluation Design within the HEAL Prevention Cooperative

Affiliations

¹ RTI International, E. Cornwallis Rd, PO Box 12194, Research Triangle Park, NC, 27709-2194, USA. ljd@rti.org.
² University of Washington, Seattle, WA, USA.
³ The University of North Carolina at Chapel Hill, School of Government of Chapel Hill, NC, USA.
⁴ Soffer Clinical Research Center, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
⁵ Heller School for Social Policy and Management, Brandeis University, Waltham, MA, USA.
⁶ Oregon Social Learning Center, Eugene, OR, USA.
⁷ Yale School of Medicine, New Haven, CT, USA.
⁸ RTI International, E. Cornwallis Rd, PO Box 12194, Research Triangle Park, NC, 27709-2194, USA.
⁹ Emory University School of Public Health, Atlanta, GA, USA.
¹⁰ Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, USA.
¹¹ Susan B. Meister Child Health Evaluation and Research (CHEAR) Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
¹² Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
¹³ RAND Corporation, Santa Monica, CA, USA.
¹⁴ Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA.

PMID: 35947282
PMCID: PMC9364296
DOI: 10.1007/s11121-022-01400-5

Economic Evaluation Design within the HEAL Prevention Cooperative

Laura J Dunlap et al. Prev Sci. 2023 Oct.

. 2023 Oct;24(Suppl 1):50-60.

doi: 10.1007/s11121-022-01400-5. Epub 2022 Aug 10.

Authors

Affiliations

¹ RTI International, E. Cornwallis Rd, PO Box 12194, Research Triangle Park, NC, 27709-2194, USA. ljd@rti.org.
² University of Washington, Seattle, WA, USA.
³ The University of North Carolina at Chapel Hill, School of Government of Chapel Hill, NC, USA.
⁴ Soffer Clinical Research Center, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
⁵ Heller School for Social Policy and Management, Brandeis University, Waltham, MA, USA.
⁶ Oregon Social Learning Center, Eugene, OR, USA.
⁷ Yale School of Medicine, New Haven, CT, USA.
⁸ RTI International, E. Cornwallis Rd, PO Box 12194, Research Triangle Park, NC, 27709-2194, USA.
⁹ Emory University School of Public Health, Atlanta, GA, USA.
¹⁰ Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, USA.
¹¹ Susan B. Meister Child Health Evaluation and Research (CHEAR) Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
¹² Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
¹³ RAND Corporation, Santa Monica, CA, USA.
¹⁴ Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA.

PMID: 35947282
PMCID: PMC9364296
DOI: 10.1007/s11121-022-01400-5

Abstract

The rapid rise in opioid misuse, disorder, and opioid-involved deaths among older adolescents and young adults is an urgent public health problem. Prevention is a vital part of the nation's response to the opioid crisis, yet preventive interventions for those at risk for opioid misuse and opioid use disorder are scarce. In 2019, the National Institutes of Health (NIH) launched the Preventing Opioid Use Disorder in Older Adolescents and Young Adults cooperative as part of its broader Helping to End Addiction Long-term (HEAL) Initiative ( https://heal.nih.gov/ ). The HEAL Prevention Cooperative (HPC) includes ten research projects funded with the goal of developing effective prevention interventions across various settings (e.g., community, health care, juvenile justice, school) for older adolescent and young adults at risk for opioid misuse and opioid use disorder (OUD). An important component of the HPC is the inclusion of an economic evaluation by nine of these research projects that will provide information on the costs, cost-effectiveness, and sustainability of these interventions. The HPC economic evaluation is integrated into each research project's overall design with start-up costs and ongoing delivery costs collected prospectively using an activity-based costing approach. The primary objectives of the economic evaluation are to estimate the intervention implementation costs to providers, estimate the cost-effectiveness of each intervention for reducing opioid misuse initiation and escalation among youth, and use simulation modeling to estimate the budget impact of broader implementation of the interventions within the various settings over multiple years. The HPC offers an extraordinary opportunity to generate economic evidence for substance use prevention programming, providing policy makers and providers with critical information on the investments needed to start-up prevention interventions, as well as the cost-effectiveness of these interventions relative to alternatives. These data will help demonstrate the valuable role that prevention can play in combating the opioid crisis.

Keywords: Budget impact analysis; Cost-effectiveness; HEAL Prevention Cooperative; Helping to End Addiction Long-term (HEAL); Older adolescents and young adults; Opioid misuse; Opioid use disorder.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

1. Acharya, M., Chopra., D., Hayes, C. J., Teeter, B., & Martin, B. C. (2020). Cost-effectiveness of intranasal naloxone distribution to high-risk prescription opioid users. Value in Health, 23(4), 451–460. (ISSN 1098–3015). 10.1016/j.jval.2019.12.002 - PubMed
1. Banerjee, S., & Wright, M. D. (2020). Injectable opioid agonist treatment for patients with opioid dependence: a review of clinical and cost-effectiveness. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health. Available from: https://www.ncbi.nlm.nih.gov/books/NBK564232/ - PubMed
1. Barnett, T. E., Thompson, E. L., Litt, D. M., & Lewis, M. A. (2019). Correlates of nonmedical prescription opioid use among U.S. adolescents. American Journal of Preventive Medicine, 57(5), e175–e179. 10.1016/j.amepre.2019.05.006 - PubMed
1. Bjornestad J, McKay JR, Berg H, Moltu C, Nesvåg S. How often are outcomes other than change in substance use measured? A systematic review of outcome measures in contemporary randomised controlled trials. Drug and Alcohol Review. 2020;39:394–414. doi: 10.1111/dar.13051. - DOI - PubMed
1. Bonar EE, Coughlin L, Roche JS, Philyaw-Kotov ML, Bixler EA, Sinelnikov S, Kolosh A, Cihak MJ, Cunningham RM, Walton MA. Prescription opioid misuse among adolescents and emerging adults in the United States: A scoping review. Preventive Medicine. 2020;132:105972. doi: 10.1016/j.ypmed.2019.105972. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Economic Evaluation Design within the HEAL Prevention Cooperative

Affiliations

Economic Evaluation Design within the HEAL Prevention Cooperative

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical