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. 2022 Aug 9;55(8):1331-1333.
doi: 10.1016/j.immuni.2022.07.011.

Come on mtDNA, light my fire

Grace M E P Lawrence  1 , Caroline L Holley  1 , Kate Schroder  2
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Come on mtDNA, light my fire

Grace M E P Lawrence et al. Immunity. .
Free article

Abstract

Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, igniting NLRP3 and cGAS-STING signaling and inflammation.

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Conflict of interest statement

Declaration of interests K.S. is a co-inventor on patent applications for NLRP3 inhibitors (WO2016131098, WO2017140778, WO2018215818), which have been licensed to Inflazome Ltd, a company headquartered in Dublin, Ireland. Inflazome is developing drugs that target the NLRP3 inflammasome to address unmet clinical needs in inflammatory disease. K.S. served on the Scientific Advisory Board of Inflazome in 2016–2017 and serves as a consultant to Quench Bio, USA and Novartis, Switzerland.

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