The lung fibroblast as "soil fertilizer" in breast cancer metastasis
- PMID: 35947977
- DOI: 10.1016/j.immuni.2022.07.010
The lung fibroblast as "soil fertilizer" in breast cancer metastasis
Abstract
Fibroblasts strongly impact tumor progression, but whether they prime the pre-metastatic niche is poorly understood. In this issue of Immunity, Gong and Li et al. identify lung-specific immunosuppressive fibroblasts, which are hijacked by breast cancer cells to facilitate metastasis.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interest K.E.d.V reports research funding from Roche and is a consultant for Macomics outside the scope of this work.
Comment on
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Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.Immunity. 2022 Aug 9;55(8):1483-1500.e9. doi: 10.1016/j.immuni.2022.07.001. Epub 2022 Jul 30. Immunity. 2022. PMID: 35908547 Free PMC article.
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