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Comment
. 2022 Aug 9;55(8):1340-1342.
doi: 10.1016/j.immuni.2022.07.013.

Hold your horses! Reining in your fastest pores with caspase-7

Jeffrey Y Zhou  1 , Katherine A Fitzgerald  2
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Free article
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Hold your horses! Reining in your fastest pores with caspase-7

Jeffrey Y Zhou et al. Immunity. .
Free article

Abstract

During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid shingomyelinase (ASM)-mediated membrane repair of gasdermin and perforin pores to delay cell death.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Caspase-7 activates ASM to repair gasdermin and perforin pores.
    Nozaki K, Maltez VI, Rayamajhi M, Tubbs AL, Mitchell JE, Lacey CA, Harvest CK, Li L, Nash WT, Larson HN, McGlaughon BD, Moorman NJ, Brown MG, Whitmire JK, Miao EA. Nozaki K, et al. Nature. 2022 Jun;606(7916):960-967. doi: 10.1038/s41586-022-04825-8. Epub 2022 Jun 15. Nature. 2022. PMID: 35705808 Free PMC article.

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