Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Apr:90:101112.
doi: 10.1016/j.mam.2022.101112. Epub 2022 Aug 7.

Siglec receptors as new immune checkpoints in cancer

Michal A Stanczak  1 , Heinz Läubli  2
Affiliations
Free article
Review

Siglec receptors as new immune checkpoints in cancer

Michal A Stanczak et al. Mol Aspects Med. 2023 Apr.
Free article

Abstract

Cancer immunotherapy in the form of immune checkpoint inhibitors and cellular therapies has improved the treatment and prognosis of many patients. Nevertheless, most cancers are still resistant to currently approved cancer immunotherapies. New approaches and rational combinations are needed to overcome these resistances. There is emerging evidence that Siglec receptors could be regarded as new immune checkpoints and targets for cancer immunotherapy. In this review, we summarize the experimental evidence supporting Siglec receptors as new immune checkpoints in cancer and discuss their mechanisms of action, as well as current efforts to target Siglec receptors and their interactions with sialoglycan Siglec-ligands.

Keywords: Cancer immunotherapy; Immune checkpoint inhibitor; Innate immunity; Monoclonal antibodies; Sialic acid; Sialidase; T cells.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest H.L. received travel grants and consultant fees from BMS and Merck, Sharp and Dohme (MSD). H.L. received research support from BMS and Palleon Pharmaceuticals. H.L. is a scientific advisor of InterVenn and GlycoEra. H.L. is a co-founder of Singenavir Ltd.

Publication types

MeSH terms

Substances

LinkOut - more resources