Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Sep;41(38):4333-4335.
doi: 10.1038/s41388-022-02424-5. Epub 2022 Aug 10.

Molecular explorations of cancer biology and therapeutics at PDB-101

David S Goodsell  1   2   3   4 , Shuchismita Dutta  1   2   3 , Maria Voigt  1   2 , Christine Zardecki  5   6 , Stephen K Burley  1   2   3   7   8
Affiliations
Editorial

Molecular explorations of cancer biology and therapeutics at PDB-101

David S Goodsell et al. Oncogene. 2022 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Images from cancer-focused Molecule of the Month articles.
(left) Artistic conception of VegF signaling. VegF (magenta, top left) arrives at the potential site of a new blood vessel by traveling through the blood plasma (tan). VegF brings together two copies of VegFR (top center, lavender/yellow) to form an active dimer. Active VegFR then initiates a signal cascade that leads to intracellular phosphorylation of many proteins, including cadherin (green). The phosphorylated cadherins separate, making room for new blood vessels. Full image available at PDB-101 and in the article on Vascular Endothelial Growth Factor (VegF) and Angiogenesis [14]. (right) Trastuzumab (red/pink) antibody bound to HER2 (blue). The cell membrane is shown schematically in gray. The illustration is built from three PDB structures: the extracellular domain with the antigen-binding fragment (Fab) of trastuzumab (1n8z [15]), the kinase domain inside the cell (3pp0 [16]), and the transmembrane domain (2ks1 [17]). Image available from the article on HER2/neu and Trastuzumab [9].
See this image and copyright information in PMC

References

    1. Protein Data Bank. Crystallography: Protein Data Bank. Nat New Biol. 1971;233:223–223. - PubMed
    1. Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow G, et al. RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering, and energy sciences. Nucleic Acid Res. 2021;49:D437–D451. doi: 10.1093/nar/gkaa1038. - DOI - PMC - PubMed
    1. Westbrook JD, Soskind R, Hudson BP, Burley SK. Impact of Protein Data Bank on anti-neoplastic approvals. Drug Discov Today. 2020;25:837–50. doi: 10.1016/j.drudis.2020.02.002. - DOI - PMC - PubMed
    1. Zardecki C, Dutta S, Goodsell DS, Lowe R, Voigt M, Burley SK. PDB-101: educational resources supporting molecular explorations through biology and medicine. Protein Sci. 2022;31:129–40. doi: 10.1002/pro.4200. - DOI - PMC - PubMed
    1. Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV, et al. RCSB Protein Data Bank: celebrating 50 years of the PDB with new tools for understanding and visualizing biological macromolecules in 3D. Protein Sci. 2022;31:187–208. doi: 10.1002/pro.4213. - DOI - PMC - PubMed

Publication types