Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;11(4):753-764.
doi: 10.1007/s13668-022-00432-1. Epub 2022 Aug 11.

Effect of Antioxidant Supplementation on Endometriosis-Related Pain: A Systematic Review

Betül Sukan  1 , Yasemin Akdevelioğlu  2 , Vahide Nur Sukan  3
Affiliations

Effect of Antioxidant Supplementation on Endometriosis-Related Pain: A Systematic Review

Betül Sukan et al. Curr Nutr Rep. 2022 Dec.

Abstract

Purpose of review: This study was conducted to determine the effects of antioxidant supplementation on endometriosis-related chronic pelvic pain, dysmenorrhea, and dyspareunia.

Methods: PubMed/MEDLINE, Scopus, and Cochrane Library databases and the Google Scholar search engine were searched from early 2012 to 2022 using appropriate keywords for clinical trials receiving antioxidant supplements and reporting endometriosis-related pelvic pain (PROSPERO registration number CRD42022318924). The qualities of the included studies were evaluated using the Joanna Briggs Institute (JBI) Checklists Critical Appraisal Tools and the National Institutes of Health (NIH) quality assessment tool for before-after (Pre-Post) study with no control group. This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline.

Results: In this systematic review, 8 studies (5 RCTs and 3 non-comparative trials) published in 2012-2022 were included.

Conclusions: The studies we included showed promising results in the use of antioxidants in endometriosis-related pain. However, many scientific studies are needed for clear statements.

Keywords: Antioxidant supplementation; Chronic pelvic pain; Dysmenorrhea; Dyspareunia; Endometriosis.

PubMed Disclaimer

References

Papers of particular interest, published recently, have been highlighted as: • Of importance
    1. World Health Organization ICD-11 for mortality and morbidity statistics. 2020. https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/183821... .
    1. Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020;382:1244–56. https://doi.org/10.1056/NEJMRA1810764 . - DOI
    1. Agarwal SK, Chapron C, Giudice LC, Laufer MR, Leyland N, Missmer SA, Singh SS, Taylor HS. Clinical diagnosis of endometriosis: A call to action. Am J Obstet Gynecol. 2019;220(4):354.E1-354.E12. https://doi.org/10.1016/j.ajog.2018.12.039 . - DOI
    1. Kim JH, Han E. Endometriosis and Female Pelvic Pain. Semin Reprod Med. 2018;36(2):143–51. https://doi.org/10.1055/s-0038-1676103 . - DOI
    1. Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: Pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261–75. https://doi.org/10.1038/nrendo.2013.255 . - DOI

Publication types

LinkOut - more resources