Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 28;24(3):602.
doi: 10.3892/etm.2022.11539. eCollection 2022 Sep.

Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

Stylianos Mastronikolis  1   2 , Marina Pagkalou  3 , Panagiotis Plotas  4 , Konstantinos Kagkelaris  1 , Constantinos D Georgakopoulos  1
Affiliations
Review

Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

Stylianos Mastronikolis et al. Exp Ther Med. .

Abstract

Pseudoexfoliation syndrome (PEXS) is a systemic disease caused by defects in the extracellular matrix (ECM) remodelling process leading to the chronic deposition of extracellular, fibrillary, white flaky pseudoexfoliation material (PEXM) throughout the body. Specifically, PEXM deposits on the lens capsule cause open-angle glaucoma, cataracts and blindness in patients with PEXS. Several gene single nucleotide polymorphisms are linked to the development of PEXS in humans, including lysyl oxidase-like 1 gene, clusterin and fibulin-5. The exact reason for the PEXM generation and its resulting pathogenesis is not well understood. However, defective ECM remodelling and oxidative stress (OS) have been hypothesized as significant events leading to the PEXM. Specifically, the link between OS and PEXS has been well studied, although the investigation is still ongoing. The present review explored recent advances in various aspects of PEXS and the involvement of OS in the eye for PEXS development.

Keywords: antioxidants; extracellular matrix remodelling; eye diseases; oxidative stress; pseudoexfoliation syndrome.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Factors associated with the onset and progression of PEXS. PEXS, pseudoexfoliation syndrome.
See this image and copyright information in PMC

References

    1. Karamanos NK, Theocharis AD, Piperigkou Z, Manou D, Passi A, Skandalis SS, Vynios DH, Orian-Rousseau V, Ricard-Blum S, Schmelzer CEH, et al. A guide to the composition and functions of the extracellular matrix. FEBS J. 2021;288:6850–6912. doi: 10.1111/febs.15776. - DOI - PubMed
    1. Iozzo RV, Theocharis AD, Neill T, Karamanos NK. Complexity of matrix phenotypes. Matrix Biol Plus. 2020;6-7(100038) doi: 10.1016/j.mbplus.2020.100038. - DOI - PMC - PubMed
    1. Dvorak-Theobald G. Pseudo-exfoliation of the lens capsule: Relation to true exfoliation of the lens capsule as reported in the literature and role in the production of glaucoma capsulocuticulare. Am J Ophthalmol. 1954;37:1–12. - PubMed
    1. Roche J. Pseudo-exfoliation of the lens capsule. Br J Ophthalmol. 1968;52:265–269. doi: 10.1136/bjo.52.3.265. - DOI - PMC - PubMed
    1. Shakib M, Ashton N, Blach R. Electron microscopic study of pseudo-exfoliation of the lens capsule. Ii. Iris and ciliary body. Invest Ophthalmol. 1965;4:154–161. - PubMed