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Case Reports
. 2022 Jul 27;24(3):593.
doi: 10.3892/etm.2022.11530. eCollection 2022 Sep.

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature

Yue Wang  1 , Yun Huang  1 , Wei-Xin Cai  1 , Qian Tao  1
Affiliations
Case Reports

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature

Yue Wang et al. Exp Ther Med. .

Abstract

Benign fibrous histiocytoma (BFH) mostly occurs on the skin of the extremities, while it is unusual to manifest on the bone and mandibular involvement of BFH is even rarer. The present study reports a case of BFH in a 42-year-old female who had a slowly progressive swelling of the bilateral mandible and slight facial asymmetry over a period of 4 months. However, the outcome of this patient was unsatisfactory, with the first and second recurrence observed 16 and 46 months after surgery, respectively. The present case suggests that BFH has a risk of recurrence after transoral curettage. Regular follow-up is advised to detect tumor recurrence after the surgery of transoral curettage.

Keywords: benign fibrous histiocytoma; case report; clinical features; mandible; regular follow-up; surgical treatments.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Preoperative imaging examination of the patient. (A) Panoramic radiography image of the patient; low-density image from the premolar to molar area of the bilateral mandible (arrows), which are surrounded by sclerotic rims. (B) Axial position of cone-beam computed tomography imaging, with cortical expansion of the buccal side and even cortical defects in the involved region (arrows). (C) Panoramic radiography image of the patient 16 months after surgery, which indicates a rounded hypodense image of the apical part of the lower left first premolar (arrow). (D) Panoramic radiography image of the patient 46 months after the first surgery with a hypointense image of the apical region of the right lower second molar (arrow).
Figure 2
Figure 2
General view of the tumors removed by transoral curettage. The tumors removed from the (A) left and (B) right side of the mandible had a hyperemic surface and medium texture (scale bar=1 cm).
Figure 3
Figure 3
Pathological examination of the tumors. (A) Histology indicated that the tumors consisted of spindle-shaped cells and collagen fibers, and the former were arranged in a storiform pattern and surrounded by the latter. The arrows a and b indicated the collagen fiber and cell, respectively. (H&E staining; magnification, x200). Immunohistochemistry suggested that the tumor cells were strongly positive for (B) CD68 and (C) XIIIa factor, while they were weakly positive for (D) α-SMA and (E) desmin. (F) The tumor cells were negative for CD34 (magnification, x200; scale bars, 100 µm).
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