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. 2022 Jul 27;9(8):ofac377.
doi: 10.1093/ofid/ofac377. eCollection 2022 Aug.

Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States

Wilfredo R Matias  1 , Jacob M Koshy  2 , Ellen H Nagami  1 , Victor Kovac  1 , Letumile R Moeng  2 , Erica S Shenoy  1 , David C Hooper  1 , Lawrence C Madoff  3 , Miriam B Barshak  1 , Jennifer A Johnson  4 , Christopher F Rowley  2 , Boris Julg  1 , Elizabeth L Hohmann  1 , Jacob E Lazarus  1
Affiliations

Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States

Wilfredo R Matias et al. Open Forum Infect Dis. .

Abstract

A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.

Keywords: antiviral; monkeypox; smallpox; tecovirimat.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts of interest.

Figures

Figure 1.
Figure 1.
Cropped clinical images of case patients treated with tecovirimat. We highlight here the diverse clinical manifestations in our patients. A, Vesiculopustular lesion with surrounding satellite pustules on the foreskin of Case 1. Note additional scabbed lesion on the pubis. B, A pustular lesion on the arm of Case 2. C, The erythematous perineal rash that prompted administration of broad-spectrum antibacterial for Case 3. Not pictured is the vesicular component.
See this image and copyright information in PMC

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