Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 25;11(3):228-239.
doi: 10.7762/cnr.2022.11.3.228. eCollection 2022 Jul.

Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mohammad Reza Amini  1 , Fatemeh Sheikhhossein  2 , Alireza Talebyan  3 , Elham Bazshahi  4 , Farhang Djafari  4 , Azita Hekmatdoost  5
Affiliations

Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mohammad Reza Amini et al. Clin Nutr Res. .

Abstract

Studies examining the effect of artichoke on liver enzymes have reported inconsistent results. This systematic review and meta-analysis aimed to assess the effects of artichoke administration on the liver enzymes. PubMed, Embase, the Cochrane Library, and Scopus databases were searched for articles published up to January 2022. Standardized mean difference (Hedges' g) were analyzed using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were assessed for the liver enzymes. Pooled analysis of seven randomized controlled trials (RCTs) suggested that the artichoke administration has an effect on both alanine aminotransferase (ALT) (Hedges' g, -1.08; 95% confidence interval [CI], -1.76 to -0.40; p = 0.002), and aspartate aminotransferase (AST) (Hedges' g, -1.02; 95% CI, -1.76 to -0.28; p = 0.007). Greater effects on ALT were detected in trials that lasted ≤8 weeks. Also, greater effects on AST were detected in trials using > 500 mg artichoke. Overall, this meta-analysis demonstrated artichoke supplementation decreased ALT and AST.

Keywords: Alanine aminotransferase; Artichoke; Aspartate aminotransferase; Liver enzymes.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Flow chart of the number of studies identified and selected into the meta-analysis.
Figure 2
Figure 2. Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the effect of artichoke supplementation on ALT.
SMD, standardized mean difference; CI, confidence interval.
Figure 3
Figure 3. Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the effect of artichoke supplementation on AST.
SMD, standardized mean difference; CI, confidence interval.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Krawczyk M, Bonfrate L, Portincasa P. Nonalcoholic fatty liver disease. Best Pract Res Clin Gastroenterol. 2010;24:695–708. - PubMed
    1. Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA. 2015;313:2263–2273. - PubMed
    1. Dyson JK, Anstee QM, McPherson S. Non-alcoholic fatty liver disease: a practical approach to diagnosis and staging. Frontline Gastroenterol. 2014;5:211–218. - PMC - PubMed
    1. Machado MV, Cortez-Pinto H. Non-alcoholic fatty liver disease: what the clinician needs to know. World J Gastroenterol. 2014;20:12956–12980. - PMC - PubMed
    1. Jadeja R, Devkar RV, Nammi S. Herbal medicines for the treatment of nonalcoholic steatohepatitis: current scenario and future prospects. Evid Based Complement Alternat Med. 2014;2014:648308. - PMC - PubMed