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Review
. 2022 Jul 31;37(4):e440.
doi: 10.5001/omj.2022.22. eCollection 2022 Jul.

Prevalence of Methicillin-resistant Staphylococcus Aureus in India: A Systematic Review and Meta-analysis

Sharanagouda S Patil  1 , Kuralayanapalya Puttahonnappa Suresh  1 , Rajamani Shinduja  1 , Raghavendra G Amachawadi  2 , Srikantiah Chandrashekar  3 , Sushma Pradeep  4 , Shiva Prasad Kollur  5 , Asad Syed  6 , Richa Sood  7 , Parimal Roy  1 , Chandan Shivamallu  4
Affiliations
Review

Prevalence of Methicillin-resistant Staphylococcus Aureus in India: A Systematic Review and Meta-analysis

Sharanagouda S Patil et al. Oman Med J. .

Abstract

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has increased and become a serious concern worldwide, including India. Additionally, MRSA isolates are showing resistance to other chemotherapeutic agents. Isolated and valuable reports on the prevalence of MRSA are available in India. There is no systematic review on the prevalence of MRSA in one place; hence, this study was planned. The overall prevalence of MRSA in humans in India was evaluated state-wise, zone-wise, and year-wise. A systematic search from PubMed, Indian journals, Google Scholar, and J-Gate Plus was carried out and retrieved 98 eligible articles published from 2015 to 2020 in India. The statistical analysis of data was conducted using R software. The overall prevalence of MRSA was 37% (95% CI: 32-41) from 2015 to 2019. The pooled prevalence of MRSA zone-wise was 41% (95% CI: 33-50), 43% (95% CI: 20-68), 33% (95% CI: 24-43), 34% (95% CI: 26-42), 36% (95% CI: 25-47), and 40% (95% CI: 23-58) for north, east, west, south, central, and northeast region-zones, respectively. The state-wise stratified results showed a predominance of MRSA in Jammu and Kashmir with 55% (95% CI: 42-67) prevalence, and the lowest was 21% (95% CI: 11-34) in Maharashtra. The study indicated that the prevalence data would help in formulating and strict implementation of control measures in hospital areas to prevent the outbreak of MRSA infection and management of antibiotic usage.

Keywords: Antimicrobial resistance; Humans; India; Meta-analysis; Methicillin-Resistant; Prevalence; Staphylococcus aureus.

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Figures

Figure 1
Figure 1
Systematic review and meta-analysis.
Figure 2
Figure 2
Heterogeneity assessment.
Figure 3
Figure 3
Zone analysis.
Figure 4
Figure 4
Galbraith plot assessment between study reports.
See this image and copyright information in PMC

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