Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 21;1(3):88-96.
doi: 10.14744/hf.2020.2020.0026. eCollection 2020 Sep.

Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases

Bulent Degertekin  1 , Nurdan Tozun  1 , Aysegul Gizem Soylemez  2 , Ezgi Gurtay  2 , Ugur Bozkurt  2 , Yusuf Yilmaz  3 , Suna Yapali  1 , Eser Vardareli  1 , Hakan Umit Unal  1 , Berkan Colakoglu  2 , Can Berk Alpaydin  2
Affiliations

Regular coffee intake improves liver enzyme levels and liver histology in patients with chronic alcohol consumption, non-alcoholic fatty liver and non-alcoholic steatohepatitis: Report of 259 cases

Bulent Degertekin et al. Hepatol Forum. .

Abstract

Background and aim: This study aims to investigate the effects of chronic coffee consumption (>5 years) and type of coffee in non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFLD) and patients who have regular alcohol consumption.

Materials and methods: In this study, 158 healthy individuals and 101 patients with histologically proven NASH were enrolled. The daily amount of coffee intake, amount of alcohol use and type of coffee were calculated for all patients. The degree of steatosis and fibrosis was analyzed by transient elastography and liver ultrasound in non-NASH and by liver biopsy in NASH patients.

Results: Patients with a history of coffee consumption (n=132) had lower liver enzyme levels compared to the non-coffee group (n=127) (p=0.001). Serum ALT level was significantly lower [ALT: 21.2±11.7 U/L vs. 56.4±15.6 U/L (p=0.004)], and the liver histopathology was significantly better for patients with a coffee consumption of daily for >5years (p=0.045 for fibrosis score for NASH, p=0.036 for LSM and p=0.015 for CAP measurements for the non-NASH patient).

Conclusion: Coffee seems to have a positive protective effect on liver histology and liver enzyme levels in healthy individuals, in patients with chronic alcohol consumption, NAFLD and NASH. These results are more prominent in patients who drink coffee on a regular daily base for more than five years.

Keywords: Alcohol; coffee; fatty liver.

PubMed Disclaimer

Conflict of interest statement

The authors does mot have any conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Freedman ND, Park Y, Abnet CC, Hollenbeck AR, Sinha R. Association of coffee drinking with total and cause-specific mortality. N Engl J Med. 2012;366(20):1891–904. - PMC - PubMed
    1. Ong A, Wong VW, Wong GL, Chan HL. The effect of caffeine and alcohol consumption on liver fibrosis-a study of 1045 Asian hepatitis B patients using transient elastography. Liver Int. 2011;31(7):1047–1053. - PubMed
    1. La Vecchia C, Ferraroni M, Negri E, D’Avanzo B, Decarli A, Levi F, et al. Coffee consumption and digestive tract cancers. Cancer Res. 1989;49(4):1049–1051. - PubMed
    1. Kuper H, Tzonou A, Kaklamani E, Hsieh CC, Lagiou P, Adami HO, et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer. 2000;85(4):498–502. - PubMed
    1. Montella M, Polesel J, La Vecchia C, Dal Maso L, Crispo A, Crovatto M, et al. Coffee and tea consumption and risk of hepatocellular carcinoma in Italy. Int J Cancer. 2007;120(7):1555–1559. - PubMed

LinkOut - more resources