Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 6;14(7):e26622.
doi: 10.7759/cureus.26622. eCollection 2022 Jul.

A Step Toward the Exploration of Better Spirometric Parameters for Early Diagnosis of Pulmonary Dysfunction in Persons With Type 2 Diabetes Mellitus

Rashmi R Dash  1 , Bandita Panda  2 , Madhuri Panigrahi  3 , Biswaranjan Nayak  4
Affiliations

A Step Toward the Exploration of Better Spirometric Parameters for Early Diagnosis of Pulmonary Dysfunction in Persons With Type 2 Diabetes Mellitus

Rashmi R Dash et al. Cureus. .

Abstract

Objectives: This study aims to determine the forced vital capacity (FVC) and slow vital capacity (SVC) along with other pulmonary functions in Indian diabetic patients for early diagnosis of pulmonary function reduction and to compare the ratios of forced expiratory volume in one second (FEV1) with FVC and SVC (FEV1/FVC and FEV1/SVC) in diabetic patients.

Materials and methods: A prospective observational study was carried out in the physiology department for two years after the approval of the institutional ethics committee. The study included 90 type 2 diabetes mellitus patients previously diagnosed by the physician and 90 age and sex-matched controls for spirometric tests. Medspiror having Helios 401 software (Recorders & Medicare Systems Pvt. Ltd., Panchkula, India) was used to assess the pulmonary function in all subjects. A comparison of dynamic pulmonary function parameters among non-diabetic and diabetic groups and non-obese vs. overweight/obese individuals of the diabetic group has been done. FEV1/FVC ratio vs. FEV1/SVC ratio comparison was conducted between the non-obese vs. the overweight/obese group in diabetic patients.

Results: A significant variation in FEV1 and FVC was observed in the type 2 diabetic group as compared to the non-diabetic group. However, in the case of type 2 diabetic subjects, FEV1/FVC ratio was almost constant in both BMI groups, whereas the FEV1/SVC ratio increased in the overweight/obese group.

Conclusion: Type 2 diabetes mellitus accounts for a predictive factor for worsening pulmonary function. SVC, particularly the FEV1/SVC ratio, can be an earlier diagnostic marker for pulmonary dysfunction in diabetic subjects as this ratio changes even with a constant FEV1/FVC ratio.

Keywords: body mass index (bmi); forced expiratory volume (fev1); forced vital capacity (fvc); slow vital capacity (svc); type 2 diabetes; type 2 diabetes mellites.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Comparative pulmonary function parameters among non-obese (<25 kg/m2) and obese (>25 kg/m2) patients in the diabetic group.
FVC: forced vital capacity; SVC: slow vital capacity; FEV1: forced expiratory volume in one second.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. WHO. Diabetes. [ Nov; 2022 ];https://www.who.int/health-topics/diabetes#tab=tab_1 2021 Diabetes,:2021–2010.
    1. Diabetic lung disease: fact or fiction? Kolahian S, Leiss V, Nürnberg B. Rev Endocr Metab Disord. 2019;20:303–319. - PMC - PubMed
    1. Classification and diagnosis of diabetes: standards of medical care in diabetes—2018. American Diabetes Association. Diabetes Care. 2018;41:0–27. - PubMed
    1. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Lim S, Bae JH, Kwon HS, Nauck MA. https://doi.org/10.1038/s41574-020-00435-4. Nat Rev Endocrinol. 2021;17:11–30. - PMC - PubMed
    1. The diabetic lung--a new target organ? Pitocco D, Fuso L, Conte EG, et al. Rev Diabet Stud. 2012;9:23–35. - PMC - PubMed

LinkOut - more resources