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. 2021 Dec 24;37(1):129-135.
doi: 10.46497/ArchRheumatol.2022.8916. eCollection 2022 Mar.

Prediction of subclinical left ventricular dysfunction by speckle-tracking echocardiography in patients with anti-neutrophil cytoplasmic antibody--associated vasculitis

Tuba Nur İzgi  1 , Dilek Barutcu Ataş  2 , Halil Ataş  3 , Dursun Akaslan  3 , Can Ilgın  4 , Arzu Velioğlu  2 , Hakkı Arıkan  2 , Fatma Alıbaz-Öner  5 , Haner Direskeneli  5 , Serhan Tuğlular  2 , Ebru Aşıcıoğlu  2
Affiliations

Prediction of subclinical left ventricular dysfunction by speckle-tracking echocardiography in patients with anti-neutrophil cytoplasmic antibody--associated vasculitis

Tuba Nur İzgi et al. Arch Rheumatol. .

Abstract

Objectives: This study aims to evaluate left ventricular functions using speckle-tracking echocardiography (STE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Patients and methods: Between June 2018 and July 2019, a total of 31 AAV patients (17 males, 14 females; median age: 53 years; range, 47 to 62 years) and 21 healthy controls (11 males, 10 females; median age: 56 years; range, 46 to 60 years) were included in the study. Clinical and biochemical characteristics of all participants were recorded. All participants underwent conventional and two-dimensional STE. The receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value of serum N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) that predicted subclinical left ventricular dysfunction. The Spearman correlation analysis was used to determine the correlation between left ventricular global longitudinal strain (LV-GLS) and NT-pro-BNP.

Results: The LV-GLS was lower in AAV patients (19.3% vs. 21.7%, respectively; p=0.014). NT-pro-BNP was negatively correlated with LV-GLS (p=0.005, r=0.401).

Conclusion: Subclinical left ventricular dysfunction can be detected by STE in patients with AAV who have free of clinically overt cardiovascular disease. The LV-GLS is negatively correlated with serum NT-pro-BNP levels.

Keywords: Anti-neutrophil cytoplasmic antibody-associated vasculitis; cardiovascular risk; speckle-tracking echocardiography; strain..

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Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. Correlation analysis showing that LV-GLS is inversely correlated with NT-pro-BNP. LV-GLS: Left ventricular global longitudinal strain; NT-pro-BNP: N-terminal prohormone of brain natriuretic peptide.
Figure 2
Figure 2. The ROC curve showing that NT-proBNP >42.5 pg/mL can predict subclinical myocardial dysfunction with 87.5% sensitivity and 69.5% specificity (Area under ROC curve= 0.695 (95% CI: 0.544-0.846). ROC: Receiver operating characteristic; NT-pro-BNP: N-terminal prohormone of brain natriuretic peptide.
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